2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Muscarinic M4 modulator-1

Muscarinic M4 modulator-1 is a Muscarinic M4 receptor positive allosteric modulator. Muscarinic M4 modulator-1 activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 Nm in CHO-K1 cells and HEK293 cells. Muscarinic M4 modulator-1 has an antipsychotic-like activity, promising for psychiatric and/or neurological disorders research.

For research use only. We do not sell to patients.

Muscarinic M4 modulator-1 Chemical Structure

Muscarinic M4 modulator-1 Chemical Structure

CAS No. : 3082186-91-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Muscarinic M4 modulator-1 Related Antibodies

Top Publications Citing Use of Products

View All mAChR Isoform Specific Products:

View All Isoforms
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Muscarinic M4 modulator-1 is a Muscarinic M4 receptor positive allosteric modulator. Muscarinic M4 modulator-1 activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 Nm in CHO-K1 cells and HEK293 cells. Muscarinic M4 modulator-1 has an antipsychotic-like activity, promising for psychiatric and/or neurological disorders research[1].

IC50 & Target

mAChR4

 

In Vitro

Muscarinic M4 modulator-1 (Example 4) (0.2-4 h) activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 nM for Muscarinic M4 receptor in CHO-K1 cells and HEK293 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Muscarinic M4 modulator-1 Related Antibodies
In Vivo

Muscarinic M4 modulator-1 (Example 4) (10-30  mg/kg, i.p., once) has antipsychotic-like activitywith 33.9% and 66.7% receptor occupancy at 10 and 30 mg/kg in rats model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1].
Dosage: 10, 30 mg/kg
Administration: i.p., once following administering intravenously with MK-6884 (3 μg/Kg) through lateral tail vein at Tmax.
Result: Caused 33.9% and 66.7% receptor occupancy at 10 and 30 mg/kg in rats.
Molecular Weight

412.44

Formula

C21H22F2N6O
CAS No.
SMILES

CC1=CC2=NC(C)=NN2C3=C1CN(C(CC4CN(C5=CC(C(F)F)=NC=C5)C4)=O)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Muscarinic M4 modulator-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muscarinic M4 modulator-13082186-91-9mAChRMuscarinic acetylcholine receptorPositive allosteric modulatorMuscarinic M4 receptorAntipsychoticCHO-K1 cellsHEK293 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Muscarinic M4 modulator-1
Cat. No.:
HY-174259
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.