M6PR Antibody (YA3870)

M6PR Antibody (YA3870) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to M6PR.

M6PR, a crucial player in cellular transport processes, facilitates the movement of phosphorylated lysosomal enzymes from both the Golgi complex and the cell surface to lysosomes. This intricate system relies on lysosomal enzymes carrying phosphomannosyl residues, which selectively bind to mannose-6-phosphate receptors within the Golgi apparatus. The ensuing formation of receptor-ligand complexes is then transported to an acidic prelyosomal compartment, where the low pH environment triggers the dissociation of these complexes. Notably, M6PR functions as a homodimer and interacts with adaptor proteins GGA1, GGA2, and GGA3 to contribute to the precision of this intricate transport mechanism.

P20645

Predicted band size: 31 kDa; Observed band size: 42 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse

WB: 1/500-1/2000; IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant fragment of human M6PR (AA: 124-277) expressed in E. Coli.