2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling Cytoskeleton NF-κB Metabolic Enzyme/Protease
  3. Transmembrane Glycoprotein STAT Collagen Reactive Oxygen Species (ROS) Interleukin Related
  4. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 

Cat. No.: HY-P990294 Purity: 95.00%
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Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis.

For research use only. We do not sell to patients.

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Chemical Structure

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Chemical Structure

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Description

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis[1][2][3].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
IC50 & Target[3]

IL-1β

 

IL-6

 

p-STAT3

 

Collagen I

 

Collagen III

 

In Vitro

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (25 μg/mL, 4 h) can significantly inhibit VCAM-1 mediated monocyte adhesion with an inhibition rate of 52 % in TNF-α activated murine cardiac endothelial cells (MCEC) cells[1].
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (20 μg/mL, 10 h) can block bone marrow-derived macrophages (BMDMs) migration[2].
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (5 μg/mL, 10 h) significantly inhibits Ang II induced BMDMs adhesion and migration[3].
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (5 μg/mL, 24 h) inhibits myocardial cell hypertrophy and fibroblast activation by reducing macrophage derived inflammatory factors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Related Antibodies

Cell Migration Assay [2]

Cell Line: BMDMs
Concentration: 20 μg/mL
Incubation Time: 10 h
Result: Significantly reduced the number of macrophage migration caused by VCAM-1.

Cell Migration Assay [3]

Cell Line: BMDMs
Concentration: 5 μg/mL
Incubation Time: 10 h
Result: Significantly reduced the number of cell migrations caused by Ang II.

Western Blot Analysis[2]

Cell Line: Rat cardiomyocytes and cardiac fibroblasts
Concentration: 5 μg/mL
Incubation Time: 24 h
Result: Reduced the level of CaNA, p-STAT3, TGF-β1 and p-Smad2/3.

RT-PCR[2]

Cell Line: Rat cardiomyocytes and cardiac fibroblasts
Concentration: 5 μg/mL
Incubation Time: 24 h
Result: Reduced the level of ANF, BNP, collagen I and collagen III.
In Vivo

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (6.85 μg/eye, intravitreal injection, single dose, immediately after the second laser) significantly reduces fibrosis area and macrophage infiltration in C57BL/6J mice with a laser-induced subretinal fibrosis model[2].
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (0.1 mg or 0.2 mg, i.p., once every 2 days, for 14 days) dose dependently improves cardiac dysfunction and reduces cardiac inflammation and fibrosis in wild-type male C57BL/6J mice with a Ang II induced hypertensive cardiac remodeling model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Laser induced C57BL/6J mice[2]
Dosage: 6.85 μg/eye
Administration: Intravitreal injection, single dose immediately after the second laser
Result: Significantly reduced the area of collagen-1 positive fibrosis.
Reduced F4/80+ macrophage infiltration.
Animal Model: Ang II (1,000 ng/kg/min, s.c., for 14 days) implanted wild-type male C57BL/6J mice[3]
Dosage: 0.1 mg or 0.2 mg
Administration: Intraperitoneal injection (i.p.), once every 2 days, for 14 days
Result: Improved the heart function decline caused by Ang II.
Reduced heart weight/body weight ratio and ANF/BNP/MYH7 mRNA expression.
Inhibited collagen deposition, collagen III, and α-SMA expression.
Reduced CD68+/VLA-4+ macrophage infiltration, IL-1β/IL-6/TNF-α mRNA expression, and ROS generation.
Gene ID

22329  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)Transmembrane GlycoproteinSTATCollagenReactive Oxygen Species (ROS)Interleukin RelatedILCD106/VCAM-1STAT3ROScollagenfibrosisBMDMInhibitorinhibitorinhibit

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