2. Stem Cell/Wnt
  3. Hedgehog
  4. HL2-m5

HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli-controlled gene with an IC50 of 230 nM.

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Custom Peptide Synthesis

HL2-m5

HL2-m5 Chemical Structure

CAS No. : 2130846-15-8

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HL2-m5 Related Antibodies

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Description

HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli-controlled gene with an IC50 of 230 nM[1].

Molecular Weight

1632.83

Formula

C70H101N15O24S3
CAS No.
Appearance

Solid

Sequence

Ac-Thr-Leu-Ser-Trp-cyclo[{O2beY}-Glu-Ala-Met-Asp-Met-Cys]-Thr-Asp-NH2
Sequence Shortening

Ac-TLSW-cyclo[{O2beY}EAMDMC]-TD-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (30.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6124 mL 3.0622 mL 6.1243 mL
5 mM 0.1225 mL 0.6124 mL 1.2249 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6124 mL 3.0622 mL 6.1243 mL 15.3108 mL
5 mM 0.1225 mL 0.6124 mL 1.2249 mL 3.0622 mL
10 mM 0.0612 mL 0.3062 mL 0.6124 mL 1.5311 mL
15 mM 0.0408 mL 0.2041 mL 0.4083 mL 1.0207 mL
20 mM 0.0306 mL 0.1531 mL 0.3062 mL 0.7655 mL
25 mM 0.0245 mL 0.1225 mL 0.2450 mL 0.6124 mL
30 mM 0.0204 mL 0.1021 mL 0.2041 mL 0.5104 mL
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HL2-m5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HL2-m52130846-15-8HedgehogInhibitorinhibitorinhibit

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