2. PROTAC
  3. PROTAC Linkers
  4. m-PEG12-NHS ester

m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG12-NHS ester

m-PEG12-NHS ester Chemical Structure

CAS No. : 2207596-93-6

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Based on 1 publication(s) in Google Scholar

m-PEG12-NHS ester Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

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Description

m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG12-NHS ester Related Antibodies
Molecular Weight

685.75

Formula

C30H55NO16
CAS No.
Appearance

Solid

Color

Colorless to off-white

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (145.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4583 mL 7.2913 mL 14.5826 mL
5 mM 0.2917 mL 1.4583 mL 2.9165 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (239 KB) HNMR (276 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4583 mL 7.2913 mL 14.5826 mL 36.4564 mL
5 mM 0.2917 mL 1.4583 mL 2.9165 mL 7.2913 mL
10 mM 0.1458 mL 0.7291 mL 1.4583 mL 3.6456 mL
15 mM 0.0972 mL 0.4861 mL 0.9722 mL 2.4304 mL
20 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.8228 mL
25 mM 0.0583 mL 0.2917 mL 0.5833 mL 1.4583 mL
30 mM 0.0486 mL 0.2430 mL 0.4861 mL 1.2152 mL
40 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.9114 mL
50 mM 0.0292 mL 0.1458 mL 0.2917 mL 0.7291 mL
60 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6076 mL
80 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.4557 mL
100 mM 0.0146 mL 0.0729 mL 0.1458 mL 0.3646 mL
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m-PEG12-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG12-NHS ester2207596-93-6PROTAC LinkersInhibitorinhibitorinhibit

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