Pep2m 

Pep2m is a peptide receptor inhibitor. Pep2m inhibits the interaction between the C-terminus of the AMPA-type glutamate receptor (GluA2) subunit and N-ethylmaleimide-sensitive fusion protein (NSF). Pep2m prevents synaptic long-term depression (LTD). Pep2m can reduce postsynaptic currents in neurons, AMPA-mediated currents in cultured hippocampal neurons, and AMPA receptor surface expression^{[1][2][3][4][5]}.

Pep2m reduces EPSC amplitude and blocks LTD in CA1 pyramidal cells of hippocampal slices by reducing the number of functional AMPARs^[1].

Pep2m reduces the current response to locally applied AMPA in cultured hippocampal neurons^[2].

Pep2m reduces the frequency of recorded AMPA-miniature excitatory postsynaptic currents (mEPSCs) in the presence of tetrodotoxin (TTX)^[2].

Pep2m reduces the surface expression of AMPA receptors containing AMPA-type glutamate receptors (GluR2), but does not reduce the surface expression of NMDA receptors and the ingrowth aggregation of AMPA receptors^[2].

Pep2m does not affect basal synaptic transmission and low-frequency stimulation (LFS)-induced LTD in young GluA2 KO mice, and does not affect basal synaptic transmission but restores LFS-induced LTD in mature GluA2 KO mice^[3].

Pep2m reduces AMPA-induced radiolabeled norepinephrine ([³H]NA) but not AMPA-induced radiolabeled acetylcholine ([³H]Ach) release^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pep2m (1 μL of 450 nM, ICV, once) impairs learning rate and long-term memory expression in male C57B6J mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1173.43

C₄₉H₉₂N₁₈O₁₃S

243843-42-7

Lys-Arg-Met-Lys-Val-Ala-Lys-Asn-Ala-Gln

KRMKVAKNAQ

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lüthi A, et al.Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 1999 Oct;24(2):389-99.  [Content Brief]

  [2]. Noel J, et al.Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron. 1999 Jun;23(2):365-76.  [Content Brief]

  [3]. Cao F, et al. Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors. Front Synaptic Neurosci. 2018 Nov 13;10:41.  [Content Brief]

  [4]. Conboy L, et al. Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action. Neuropsychopharmacology. 2010 Feb;35(3):674-85.  [Content Brief]

  [5]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96.  [Content Brief]