2. PROTAC
  3. PROTAC Linkers
  4. m-PEG4-phosphonic acid

m-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG4-phosphonic acid

m-PEG4-phosphonic acid Chemical Structure

CAS No. : 1872433-62-9

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Based on 1 publication(s) in Google Scholar

m-PEG4-phosphonic acid Related Antibodies

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Description

m-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG4-phosphonic acid Related Antibodies
Molecular Weight

272.23

Formula

C9H21O7P
CAS No.
Appearance

Solid

SMILES

COCCOCCOCCOCCP(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (91.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6734 mL 18.3668 mL 36.7336 mL
5 mM 0.7347 mL 3.6734 mL 7.3467 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6734 mL 18.3668 mL 36.7336 mL 91.8341 mL
5 mM 0.7347 mL 3.6734 mL 7.3467 mL 18.3668 mL
10 mM 0.3673 mL 1.8367 mL 3.6734 mL 9.1834 mL
15 mM 0.2449 mL 1.2245 mL 2.4489 mL 6.1223 mL
20 mM 0.1837 mL 0.9183 mL 1.8367 mL 4.5917 mL
25 mM 0.1469 mL 0.7347 mL 1.4693 mL 3.6734 mL
30 mM 0.1224 mL 0.6122 mL 1.2245 mL 3.0611 mL
40 mM 0.0918 mL 0.4592 mL 0.9183 mL 2.2959 mL
50 mM 0.0735 mL 0.3673 mL 0.7347 mL 1.8367 mL
60 mM 0.0612 mL 0.3061 mL 0.6122 mL 1.5306 mL
80 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1479 mL
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m-PEG4-phosphonic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG4-phosphonic acid1872433-62-9PROTAC LinkersInhibitorinhibitorinhibit

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