2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. ER-67880

ER-67880 is a potent microtubule inhibitor. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes, suggesting potential dehydrogenase inhibitory activity. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma.

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ER-67880

ER-67880 Chemical Structure

CAS No. : 247186-96-5

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Description

ER-67880 is a potent microtubule inhibitor. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes, suggesting potential dehydrogenase inhibitory activity. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma[1].
Molecular Weight

336.79

Formula

C15H13ClN2O3S
CAS No.
SMILES

O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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ER-67880 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ER-67880247186-96-5ER67880ER 67880Microtubule/TubulinKBColon 38P338 cellsG2/M phase arrestdehydrogenaseInhibitorinhibitorinhibit

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