2. Others
  3. Drug Derivative
  4. RX 336M

RX 336M is a dihydrocodeinone analogue. RX 336M induces behaviors consisting of consisting of behavioral activation, rapid forepaw movements, excessive grooming, and whole body "wet-dog" shakes (WDS) (rapid twisting of the head and trunk with the forepaws leaving the ground). RX 336M can be used for the study of neurological disease.

For research use only. We do not sell to patients.

RX 336M

RX 336M Chemical Structure

CAS No. : 6701-66-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

RX 336M Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RX 336M is a dihydrocodeinone analogue. RX 336M induces behaviors consisting of consisting of behavioral activation, rapid forepaw movements, excessive grooming, and whole body "wet-dog" shakes (WDS) (rapid twisting of the head and trunk with the forepaws leaving the ground). RX 336M can be used for the study of neurological disease[1][2].

In Vivo

RX 336M (1.5-12 mg/kg, i.p., single dose) induces dose-, age- and sex-related "wet-dog" shakes and excessive grooming in rats[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (weight ranges: 80-90 g, 120-140 g, 190-210 g, 280-300 g)[1]
Dosage: 1.5, 3, 6, 12 mg/kg
Administration: i.p. for a single dose
Result: Induced grooming behavior that primarily involved face washing and preening of the flanks with the mouth or forepaws, with very little hindpaw scratching.
Caused a sequential behavioral pattern in rats: shaking first, followed by face washing, then grooming of the flanks, and repetition of this sequence.
Led to a decrease in the correlation between the number of "wet-dog" shakes (WDS) and the percentage of maximum possible grooming episodes (%MGE).
Showed improved correlation between WDS and %MGE in rats weighing 190-210 g and 280-300 g.
Increased the number of WDS but decreased the correlation between WDS and grooming when the dose was doubled to 12 mg/kg in large rats.
Resulted in a decline in %MGE but an improvement in the correlation between shaking and grooming.
Animal Model: Male and female Long-Evans rats of different ages (21 days, 30 days, 39 days, and 48 days old)[2]
Dosage: 6 mg/kg
Administration: i.p. for a single dose
Result: Induced more significant excessive grooming in younger rats than in older ones, with gender differences.
Caused age- and sex-related differences in the frequency of "wet-dog" shakes (WDS).
Had no significant effect on the activity levels (rearing and locomotion) of rats, while female rats generally had higher activity levels than males.
Animal Model: 39-day-old female Long-Evans rats received daily subcutaneous injections of testosterone benzoate (1 mg/kg/day) for 8 consecutive days starting from 32 days old[2]
Dosage: 6 mg/kg
Administration: i.p. for a single dose
Result: Enhanced the responses of female rats to excessive grooming and "wet-dog" shakes.
Had no significant behavioral effects in 39-day-old female rats pretreated with oil vehicle.
Molecular Weight

379.49

Formula

C24H29NO3
CAS No.
SMILES

O=C1C2OC3=C(C=CC(CC4C5(C6C1)CCC(C)=C6C)=C3C25CCN4C)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

RX 336M Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX 336M6701-66-2Drug DerivativeDrug derivativedihydrocodeinonequasi-morphine withdrawal syndromeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
RX 336M
Cat. No.:
HY-122125
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.