2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Ferroptosis Reactive Oxygen Species (ROS)
  4. 1,4-Naphthoquinone-NH-C2-NH-Trolox

1,4-Naphthoquinone-NH-C2-NH-Trolox is a brain-penetrant Trolox (HY-101445)-vitamin K (HY-B2172) conjugate with neuroprotective activity. 1,4-Naphthoquinone-NH-C2-NH-Trolox can inhibit oxytosis, ferroptosis, ATP depletion and ROS production. 1,4-Naphthoquinone-NH-C2-NH-Trolox selective suppresses M1 markers expression. 1,4-Naphthoquinone-NH-C2-NH-Trolox can be used for the research of neurological disease, such as Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

1,4-Naphthoquinone-NH-C2-NH-Trolox

1,4-Naphthoquinone-NH-C2-NH-Trolox Chemical Structure

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1,4-Naphthoquinone-NH-C2-NH-Trolox Related Antibodies

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Description

1,4-Naphthoquinone-NH-C2-NH-Trolox is a brain-penetrant Trolox (HY-101445)-vitamin K (HY-B2172) conjugate with neuroprotective activity. 1,4-Naphthoquinone-NH-C2-NH-Trolox can inhibit oxytosis, ferroptosis, ATP depletion and ROS production. 1,4-Naphthoquinone-NH-C2-NH-Trolox selective suppresses M1 markers expression. 1,4-Naphthoquinone-NH-C2-NH-Trolox can be used for the research of neurological disease, such as Alzheimer’s disease (AD)[1].

In Vitro

1,4-Naphthoquinone-NH-C2-NH-Trolox (Compound 16e) exhibits potent and comparable radical scavenging activity with an EC50 of 15.4 μM[1].
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.38-25 μM, 24 h) inhibit oxytosis, ferroptosis, and ATP depletion in HT22 hippocampal nerve cells[1].
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.4 μM, 8 h) reduces ROS production in HT22 cells[1].
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.5-2.5 μM, 24 h) selective suppresses M1 markers in HT22 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,4-Naphthoquinone-NH-C2-NH-Trolox Related Antibodies

Western Blot Analysis[1]

Cell Line: HT22 cells
Concentration: 0.5, 1 and 2.5 μM
Incubation Time: 24 h
Result: Dose-dependently suppressed nitrite accumulation and IL-1β release.
Attenuated LPS-induced iNOS protein upregulation.
Did not modulate expression of the M2 markers TREM2 or TGFβ2.
In Vivo

1,4-Naphthoquinone-NH-C2-NH-Trolox (Compound 16e) (0.1 mg/kg, i.p., daily for 7 days) ameliorates Aβ25-35 (HY-P0128)-induced cognitive deficits in AD mice modes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aβ25-35 (HY-P0128)-induced acuteAlzheimer’s disease (AD) mice models[1]
Dosage: 0.1 mg/kg
Administration: Intraperitoneally injection, daily for 7 days
Result: Significantly ameliorated Aβ25-35-induced working memory deficits.
Did not ameliorate Aβ25-35-induced long-term memory deficits.
Molecular Weight

448.51

Formula

C26H28N2O5
SMILES

O=C(C1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C)NCCNC(C3=O)=CC(C4=C3C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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1,4-Naphthoquinone-NH-C2-NH-Trolox Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-Naphthoquinone-NH-C2-NH-TroloxFerroptosisReactive Oxygen Species (ROS)Troloxvitamin KOxytosisATPROSHT-22Alzheimer’s diseaseInhibitorinhibitorinhibit

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