p-F-HHSiD hydrochloride  (Synonyms: p-Fluorohexahydrosiladifenidol hydrochloride)

p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a potent and selective M3 mAChR antagonist. p-F-HHSiD hydrochloride has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD hydrochloride can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes^{[1][2][3][4][5][6]}.

p-F-HHSiD (30 nM-10 μM, 60-180 mins) exerts an antagonistic effect on M₃ receptor-mediated contractile responses in tracheal tissue of guinea pigs^[1].
p-F-HHSiD (100 μM, 5 days) inhibits basal proliferation of H508 human colon cancer cells by 40% through selective blocking of M₃ muscarinic receptors^[2].
p-F-HHSiD (0.03-3 μM) significantly inhibits the positive phase of inotropic response to Ach in isolated mouse left atria^[3].
p-F-HHSiD (0.1 nM-100 μM, 90 mins) exhibits a single class of binding sites to muscarinic receptors in P2 crude synaptosomal fractions from frontal cortices (Alzheimer’s disease brains)^[4].
p-F-HHSiD (1 μM, 2 h) significantly inhibits ACh-induced contraction of isolated human umbilical vein (HUV) (gestational diabetes mellitus)^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

386.02

C₂₀H₃₃ClFNOSi

175615-76-6

Solid

White to off-white

O[Si](C1=CC=C(F)C=C1)(C2CCCCC2)CCCN3CCCCC3.[H]Cl

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9.  [Content Brief]

  [2]. Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7.  [Content Brief]

  [3]. Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66(7):607-15.  [Content Brief]

  [4]. Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596(1-2):142-8.  [Content Brief]

  [5]. He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15(1):24308.  [Content Brief]

  [6]. Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):368-71.  [Content Brief]