Alpha-2-Macroglobulin Antibody (YA3305)

Alpha-2-Macroglobulin Antibody (YA3305) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3305), targeting Alpha-2-Macroglobulin, with a predicted molecular weight of 163 kDa (observed band size: 163 kDa). Alpha-2-Macroglobulin Antibody (YA3305) can be used for WB, IHC-P experiment in human background.

Alpha-2-macroglobulin (A2M), a protease inhibitor and cytokine transporter, belongs to the MEROPS proteinase inhibitor family I39, clan IL. It is also a large plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells. The inhibitor acts on all classes of endoproteases and could potentially be used to slow or halt PTOA by neutralizing catabolic cascades in affected cartilage. A2M can enter into cells and bind to numerous cytokines, including transforming growth factor-beta 1 (TGF-β1), TGF-β2, nerve growth factor-beta, platelet-derived growth factor-BB, tumor necrosis factor-alpha (TNF-α), and basic fibroblast growth factor. A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway. A2M as a novel disease modifying protein in osteoporosis, downregulation of which in bone marrow promotes SSPC dysfunction and imbalances in skeletal homeostasis.

P01023

Predicted band size: 163 kDa; Observed band size: 163 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Cardiovascular

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human A2M