2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse/Human IL-7 Antibody (M25)

Anti-Mouse/Human IL-7 Antibody (M25) 

Cat. No.: HY-P990210 Purity: 95.00%
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Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for research on inflammation conditions such as airway inflammation.

For research use only. We do not sell to patients.

Anti-Mouse/Human IL-7 Antibody (M25)

Anti-Mouse/Human IL-7 Antibody (M25) Chemical Structure

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Description

Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for research on inflammation conditions such as airway inflammation[1][2].

Isotype

Mouse IgG2b kappa
Recommend Isotype Controls
IC50 & Target[1][2]

IL7R

 

In Vivo

Anti-Mouse/Human IL-7 Antibody (M25) (500 μg/mouse, i.p., single dose, 3 h before Papain injection) significantly reduces eosinophil infiltration and alleviates inflammation in wild-type C57BL/6 mice with a Papain (HY-P1645) induced airway inflammation[1].
Anti-Mouse/Human IL-7 Antibody (M25) (3 mg, i.p., once every 3-4 days, for 2 weeks) significantly reduces the number of B cell precursors in NSG mice injected with CD34+ cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Papain (100 μg, intranasal injection, on day 0, 1, and 2 ) induced wild-type C57BL/6 mice (8-12 weeks)[1]
Dosage: 500 μg/mouse
Administration: Intraperitoneal injection (i.p.), single dose, 3 h before Papain injection
Result: Significantly reduced eosinophil infiltration.
Reduced the expression of ST2 in innate lymphoid cells (ILC2s).
Reduced the level of IL-5.
Animal Model: NSG mice injected with CD34+ cells[2]
Dosage: 3 mg
Administration: Intraperitoneal injection (i.p.), once every 3-4 days for 2 weeks
Result: Significantly reduced the number of B cell precursors in T mice (without hTSLP).
Gene ID

16196  [NCBI]

Accession

P10168 / Q544C8 / NP_032397.1
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Human IL-7 Antibody (M25)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse/Human IL-7 Antibody (M25) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human IL-7 Antibody (M25)Interleukin RelatedILIL-7ILC2sB cellairway inflammationInhibitorinhibitorinhibit

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