2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Tasipimidine

Tasipimidine is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 for human α2A-adrenoceptors and an EC50 of 5.7 nM for rat α2-adrenoceptor. Tasipimidine can be utilized in research related to situational anxiety and fear.

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Tasipimidine Chemical Structure

Tasipimidine Chemical Structure

CAS No. : 1465908-70-6

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Tasipimidine Related Antibodies

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Description

Tasipimidine is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 for human α2A-adrenoceptors and an EC50 of 5.7 nM for rat α2-adrenoceptor. Tasipimidine can be utilized in research related to situational anxiety and fear[1][2].

IC50 & Target[1]

human α2A-adrenoceptor

7.57 (pEC50)

rat α2-adrenergic receptor

5.7 nM (EC50)

In Vivo

Tasipimidine (10-3000 μg/kg; subcutaneous injection/oral administration; single dose) reduces spontaneous locomotor activity in mice[1].
Tasipimidine (300-1000 μg/kg; subcutaneous injection; single dose) reduces the amplitude of the acoustic startle reflex in rats, with onset within 20 minutes, peak effect at 1 hour, and duration of at least 2 hours[1].
Tasipimidine (10-30 μg/kg; oral administration; total 3 treatment cycles) has an improving effect on separation anxiety in dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-habituated mice[1]
Dosage: Subcutaneous injection: 10, 30 and 100 μg/kg
Oral administration: 900 and 3000 μg/kg
Administration: Single dose
Result: Significantly reduced the activity count at doses of 30 μg/kg and higher doses, with 100 μg/kg showing a more pronounced effect by subcutaneous injection.
Significantly decreased the spontaneous locomotor activity of 3.0 mg/kg, while 0.9 mg/kg had no effect by oral administration.
Animal Model: Clinically healthy privately-owned dogs with a history of separation anxiety[2]
Dosage: 10 and 30 μg/kg
Administration: Oral administration; three 4-day treatment periods in randomized order each followed by a 3-day washout
Result: Had a statistically significant treatment effect.
Led to more positive owner ratings, significantly reduced destructive/rearranging behavior and vocalization at dose of 30 μg/kg. Most dogs remained fully responsive and able to walk normally, with no serious adverse events reported.
Clinical Trial
Molecular Weight

232.28

Formula

C13H16N2O2
CAS No.
SMILES

COC1=C2CCOC(C3=NCCN3)C2=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tasipimidine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tasipimidine1465908-70-6Adrenergic ReceptorBeta Receptorα2A-adrenoceptor agonistorally activesituational anxietyfeardogInhibitorinhibitorinhibit

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