Cyanostatin B 

Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability.^[1][2].

Cyanostatin B (0-75 μg/mL, 24 h) exhibits no toxicity to juveniles (nauplii) of the brine shrimp^[1].
Cyanostatin B (0-10 μg/mL, 24-48 h) exhibits concentration-dependent inhibition of cell proliferation after 72 hours of exposure in HepG2 cells^[2].
Cyanostatin B (0-1 μg/mL, 24-48 h) induces DNA single-strand breaks (SSBs) but not DNA double-strand breaks (DSBs) in HepG2 cells^[2].
Cyanostatin B (1 μg/mL, 24-72 h) is clastogenic, causing chromosome breakage or loss of entire chromosomes in HepG2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

753.92

C₄₀H₅₉N₅O₉

850131-23-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sano T, et al. Leucine aminopeptidase M inhibitors, cyanostatin A and B, isolated from cyanobacterial water blooms in Scotland. Phytochemistry. 2005 Mar;66(5):543-8.  [Content Brief]

  [2]. Ujvárosi AZ, et al. The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line. Chemosphere. 2020 Feb;240:124880.  [Content Brief]