2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor 5-HT Receptor
  4. SGB-1534 hydrochloride

SGB-1534 (hydrochloride) is an orally active, selective and competitive antagonist of the alpha 1-adrenoceptor and the 5-HT2 receptor. SGB-1534 (hydrochloride) can inhibit vasoconstriction and lower blood pressure. SGB-1534 (hydrochloride) can be used for the research of cardiovascular disease, such as hypertension.

For research use only. We do not sell to patients.

SGB-1534 hydrochloride

SGB-1534 hydrochloride Chemical Structure

CAS No. : 88068-72-8

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SGB-1534 hydrochloride Related Antibodies

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α adrenergic receptor β adrenergic receptor

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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Description

SGB-1534 (hydrochloride) is an orally active, selective and competitive antagonist of the alpha 1-adrenoceptor and the 5-HT2 receptor. SGB-1534 (hydrochloride) can inhibit vasoconstriction and lower blood pressure. SGB-1534 (hydrochloride) can be used for the research of cardiovascular disease, such as hypertension[1][2].

IC50 & Target[1]

α1-adrenergic receptor

 

5-HT2 Receptor

 

In Vivo

SGB-1534 (hydrochloride) (0.1-3 mg/kg, p.o.) exhibits potent and long-lasting antihypertensive effects in conscious spontaneously hypertensive rats (SHRs), renal hypertensive rats and DOCA (HY-B1472)-salt rats, but it increased the heart rate only minimally[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

416.90

Formula

C21H25ClN4O3
CAS No.
SMILES

O=C(N1CCN2CCN(C3=C(C=CC=C3)OC)CC2)C4=CC=CC=C4NC1=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGB-1534 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGB-153488068-72-8SGB1534SGB 1534Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorAdrenoceptor5-HThypertensionvasoconstrictionblood pressureInhibitorinhibitorinhibit

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