2. PROTAC
  3. PROTAC Linkers
  4. m-PEG13-NHS ester

m-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG13-NHS ester Chemical Structure

m-PEG13-NHS ester Chemical Structure

CAS No. : 3063847-98-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of m-PEG13-NHS ester:

m-PEG13-NHS ester Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

m-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG13-NHS ester Related Antibodies
Molecular Weight

729.81

Formula

C32H59NO17
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (137.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3702 mL 6.8511 mL 13.7022 mL
5 mM 0.2740 mL 1.3702 mL 2.7404 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (255 KB) HNMR (284 KB) MS (70 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3702 mL 6.8511 mL 13.7022 mL 34.2555 mL
5 mM 0.2740 mL 1.3702 mL 2.7404 mL 6.8511 mL
10 mM 0.1370 mL 0.6851 mL 1.3702 mL 3.4255 mL
15 mM 0.0913 mL 0.4567 mL 0.9135 mL 2.2837 mL
20 mM 0.0685 mL 0.3426 mL 0.6851 mL 1.7128 mL
25 mM 0.0548 mL 0.2740 mL 0.5481 mL 1.3702 mL
30 mM 0.0457 mL 0.2284 mL 0.4567 mL 1.1418 mL
40 mM 0.0343 mL 0.1713 mL 0.3426 mL 0.8564 mL
50 mM 0.0274 mL 0.1370 mL 0.2740 mL 0.6851 mL
60 mM 0.0228 mL 0.1142 mL 0.2284 mL 0.5709 mL
80 mM 0.0171 mL 0.0856 mL 0.1713 mL 0.4282 mL
100 mM 0.0137 mL 0.0685 mL 0.1370 mL 0.3426 mL
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m-PEG13-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG13-NHS ester3063847-98-0PROTAC LinkersInhibitorinhibitorinhibit

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