AF151 

AF151 is a METTL3 PROTAC degrader with the DC₅₀ of 0.43 μM in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading METTL3 protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia (AML). (Pink: METTL3 Ligand (HY-174874); Blue: VHL Ligand (HY-125845); Black: Linker; VHL Ligand+Linker (HY-174875))^[1].

AF151 (0-10 μM, 0-72 h) can efficiently degrade METTL3 protein in a time-dependent manner and significantly inhibit cell growth of MOLM-13 cells (DC₅₀ = 0.43 μM, IC₅₀ = 0.45 μM)^[1].
AF151 (2 μM, 24-48 h) can significantly reduce m6A levels in MOLM-13 cells^[1].
AF151 (0.1-5 μM, 48 h) can dose dependently induce cell apoptosis and reduce the level of anti apoptotic proteins in MOLM-13 cells^[1].
AF151 (72 h) can work synergistically with Venetoclax (HY-15531) in MOLM-13 cells^[1].
AF151 (0.001-10 μM) can promote the binding of METTL3 and VHL (AF151 = 363 nM, AF151-METTL3 = 79.9 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1043.32

C₆₁H₇₀N₈O₆S

CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(CCC4=CC=C(C5=CC=C(COC6=CN=CC(C(NCC7=CC(NC(CN8CCC(C)(C)CC8)=C9)=C9C=C7)=O)=C6)C=C5)C=C4)=O)C(C)(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Weldert AC, et al. Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. RSC Med Chem. 2025 Jun 19.  [Content Brief]