2. Others GPCR/G Protein Neuronal Signaling Apoptosis PI3K/Akt/mTOR Stem Cell/Wnt
  3. Isotope-Labeled Compounds Adrenergic Receptor Apoptosis Akt Wnt β-catenin
  4. Tizanidine-d4

Tizanidine-d4 is the deuterium labeled Tizanidine (HY-B0194). Tizanidine, a skeletal muscle relaxant, is an orally effective central α2-adrenoceptor agonist (IC50 = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

For research use only. We do not sell to patients.

Tizanidine-d<sub>4</sub>

Tizanidine-d4 Chemical Structure

CAS No. : 1188331-19-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Tizanidine-d4:

Tizanidine-d4 Related Antibodies

Top Publications Citing Use of Products

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α adrenergic receptor β adrenergic receptor

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Akt Akt1 Akt2 Akt3

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Wnt1 Wnt3 Wnt5 Wnt7

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Description

Tizanidine-d4 is the deuterium labeled Tizanidine (HY-B0194). Tizanidine, a skeletal muscle relaxant, is an orally effective central α2-adrenoceptor agonist (IC50 = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

Molecular Weight

257.74

Formula

C9H4D4ClN5S
CAS No.
Unlabeled CAS
Appearance

Solid

Color

Yellow to orange

SMILES

N(C=1C=2C(C=CC1Cl)=NSN2)C=3NC(C(N3)([2H])[2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 22.22 mg/mL (86.21 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8799 mL 19.3994 mL 38.7988 mL
5 mM 0.7760 mL 3.8799 mL 7.7598 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8799 mL 19.3994 mL 38.7988 mL 96.9970 mL
5 mM 0.7760 mL 3.8799 mL 7.7598 mL 19.3994 mL
10 mM 0.3880 mL 1.9399 mL 3.8799 mL 9.6997 mL
15 mM 0.2587 mL 1.2933 mL 2.5866 mL 6.4665 mL
20 mM 0.1940 mL 0.9700 mL 1.9399 mL 4.8498 mL
25 mM 0.1552 mL 0.7760 mL 1.5520 mL 3.8799 mL
30 mM 0.1293 mL 0.6466 mL 1.2933 mL 3.2332 mL
40 mM 0.0970 mL 0.4850 mL 0.9700 mL 2.4249 mL
50 mM 0.0776 mL 0.3880 mL 0.7760 mL 1.9399 mL
60 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.6166 mL
80 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2125 mL
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Tizanidine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tizanidine-d41188331-19-2Isotope-Labeled CompoundsAdrenergic ReceptorApoptosisAktWntβ-cateninBeta ReceptorPKBProtein kinase BBeta cateninInhibitorinhibitorinhibit

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