TXNIP Protein, Human (His, B2M)

TXNIP Protein, Human (His, B2M) is the recombinant human-derived TXNIP protein, expressed by E. coli, with N-6*His & N-B2M tag.

TXNIP acts as an oxidative stress mediator by inhibiting thioredoxin activity or limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). TXNIP functions as a transcriptional repressor, possibly by bridging transcription factors and corepressor complexes, and its overexpression induces G0/G1 cell cycle arrest. It is also required for the maturation of natural killer cells (By similarity) and acts as a suppressor of tumor cell growth. Additionally, TXNIP inhibits the proteasomal degradation of DDIT4, thereby contributing to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Human

E. coli

N-6*His;N-B2M

Q9H3M7-1 (M1-Q391)

10628

Full Length of Isoform-1

MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.