Search Result

Isoforms Recommended:	CB2

Results for "

CB<sub>2</sub>R

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (4) 15-PGDH (1) 5 alpha Reductase (6) 5-HT Receptor (196) Acetolactate Synthase (ALS) (1) Ack1 (2) Acyltransferase (1) ADC Antibody (1) ADC Cytotoxin (19) ADC Linker (27) Adenosine Receptor (38) Adenylate Cyclase (3) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (159) AIM2 (1) Akt (52) Aldehyde Dehydrogenase (ALDH) (2) Aldose Reductase (2) Amino Acid Derivatives (97) Aminoacyl-tRNA Synthetase (3) Aminopeptidase (2) Aminotransferases (Transaminases) (1) AMPK (11) Amyloid-β (19) Anaplastic lymphoma kinase (ALK) (39) Androgen Receptor (33) Angiotensin Receptor (58) Angiotensin-converting Enzyme (ACE) (27) Annexin A (1) Antibiotic (253) Antibody-Drug Conjugates (ADCs) (2) Antifolate (11) AP-1 (3) Apelin Receptor (APJ) (4) Apical Sodium-Dependent Bile Acid Transporter (3) Apoptosis (530) Arenavirus (1) Arginase (2) Arp2/3 Complex (2) Arrestin (6) Aryl Hydrocarbon Receptor (13) ASCT (2) Atg8/LC3 (3) ATM/ATR (3) ATP Citrate Lyase (2) ATP Synthase (4) ATTECs (1) Aurora Kinase (8) Autophagy (422) Bacterial (424) Bcl-2 Family (22) Bcr-Abl (19) BCRP (5) Beta-lactamase (11) Beta-secretase (4) Biochemical Assay Reagents (282) BMX Kinase (1) Bombesin Receptor (4) Bradykinin Receptor (4) Btk (24) c-Fms (73) c-Kit (34) c-Met/HGFR (21) c-Myc (2) Calcium Channel (111) Calmodulin (2) Cannabinoid Receptor (251) Carbonic Anhydrase (13) Casein Kinase (3) Caspase (24) CaSR (7) Cathepsin (3) CCR (8) CD2 (1) CD20 (2) CD28 (1) CD3 (2) CD73 (1) Cdc42-binding kinase (1) CDK (39) CFTR (20) CGRP Receptor (4) Checkpoint Kinase (Chk) (1) Chloride Channel (4) Cholecystokinin Receptor (4) Cholinesterase (ChE) (33) ClpP (2) CMV (2) Collagen (1) Complement System (14) COMT (7) Constitutive Androstane Receptor (1) COX (93) CRAC Channel (1) CRFR (13) Cuproptosis (2) CXCR (11) Cyclic GMP-AMP Synthase (1) Cyclophilin (4) Cytochrome P450 (85) DAGL (3) Dengue Virus (2) Deubiquitinase (2) Dihydrofolate reductase (DHFR) (3) Dihydroorotate Dehydrogenase (4) Dipeptidyl Peptidase (26) Discoidin Domain Receptor (4) Disulfidptosis (5) DNA Alkylator/Crosslinker (13) DNA Methyltransferase (7) DNA-PK (1) DNA/RNA Synthesis (121) Dopamine Receptor (151) Dopamine Transporter (2) Dopamine β-hydroxylase (1) Drug Derivative (39) Drug Intermediate (42) Drug Isomer (56) Drug Metabolite (130) Drug-Linker Conjugates for ADC (13) DYRK (5) E1/E2/E3 Enzyme (3) E3 Ligase Ligand-Linker Conjugates (154) EAAT (1) EBI2/GPR183 (1) EGFR (200) Elastase (2) Endogenous Metabolite (1077) Endothelin Receptor (5) Enterovirus (11) Ephrin Receptor (1) Epigenetic Reader Domain (25) Epoxide Hydrolase (1) ERK (21) Estrogen Receptor/ERR (65) Eukaryotic Initiation Factor (eIF) (1) FAAH (6) Factor Xa (9) FAK (5) Farnesyl Transferase (4) Fat Mass and Obesity-associated Protein (FTO) (1) FATP (1) Fatty Acid Synthase (FASN) (6) Fc Receptor (FcR) (1) Ferroptosis (76) FGFR (24) FKBP (9) Flavivirus (5) FLT3 (30) Fluorescent Dye (64) Free Fatty Acid Receptor (3) Fungal (129) FXR (10) G protein-coupled Bile Acid Receptor 1 (9) G Protein-coupled Receptor Kinase (GRK) (2) G-quadruplex (1) GABA Receptor (45) Gap Junction Protein (5) GCGR (53) GHSR (7) GLP Receptor (57) Glucocorticoid Receptor (34) Glucosylceramide Synthase (GCS) (2) Glutamate Dehydrogenase (GLDH) (1) Glutaminase (5) Glutathione Peroxidase (6) Glutathione Reductase (GR) (1) Glutathione S-transferase (1) Glycosidase (13) Glycosyltransferase (1) GlyT (5) GnRH Receptor (16) GPR109A (2) GPR35 (1) GPR55 (9) GPR88 (1) GSK-3 (15) Guanylate Cyclase (2) HBV (23) HCV (39) HCV Protease (5) HDAC (25) Hedgehog (7) Herbicide (7) Hexokinase (2) HIF/HIF Prolyl-Hydroxylase (12) Histamine Receptor (114) Histone Acetyltransferase (8) Histone Demethylase (11) Histone Methyltransferase (24) HIV (117) HIV Integrase (19) HIV Protease (17) HMG-CoA Reductase (HMGCR) (26) HPPD (1) HSP (5) HSV (37) Huntingtin (2) HuR (7) IAP (1) ICMT (2) IFNAR (4) IGF-1R (56) iGluR (48) IKK (4) Imidazoline Receptor (8) IMPDH (2) Indoleamine 2,3-Dioxygenase (IDO) (4) Influenza Virus (51) Insecticide (5) Insulin Receptor (22) Integrin (17) Interleukin Related (90) IPK Superfamily (2) IRE1 (1) Isocitrate Dehydrogenase (IDH) (37) Isotope-Labeled Compounds (3125) JAK (25) JNK (11) Keap1-Nrf2 (22) Ketohexokinase (2) Kinesin (2) Kisspeptin Receptor (8) Lactate Dehydrogenase (3) LDLR (2) Leukotriene Receptor (20) Ligands for E3 Ligase (43) Ligands for Target Protein for PROTAC (6) LIM Kinase (LIMK) (2) Lipase (2) Lipocalin Family (1) Liposome (29) Lipoxygenase (8) LPL Receptor (13) LRRK2 (1) LXR (3) mAChR (66) Macrophage migration inhibitory factor (MIF) (1) MAGL (2) MALT1 (4) MAP3K (3) MAP4K (1) MARK (1) Mas-related G-protein-coupled Receptor (MRGPR) (3) MCHR1 (GPR24) (9) MDM-2/p53 (14) MEK (15) Melanocortin Receptor (70) Melatonin Receptor (10) MetAP (1) mGluR (22) MHC (1) MicroRNA (4) Microsomal Triglyceride Transfer Protein (MTP) (1) Microtubule/Tubulin (31) Mineralocorticoid Receptor (13) Mitochondrial Metabolism (18) Mitophagy (49) Mitosis (7) Mixed Lineage Kinase (3) MMP (22) Molecular Glues (20) Monoamine Oxidase (29) Monoamine Transporter (6) Monocarboxylate Transporter (1) mTOR (23) Myosin (8) Na+/Ca2+ Exchanger (2) Na+/H+ Exchanger (NHE) (1) Na+/K+ ATPase (9) nAChR (24) NADPH Oxidase (3) NAMPT (3) Necroptosis (3) Neprilysin (11) Neurokinin Receptor (30) Neuromedin U Receptor (NMUR) (2) Neuropeptide FF Receptor (8) Neuropeptide Y Receptor (27) Neurotensin Receptor (5) NF-κB (63) NKCC (2) NO Synthase (39) NOD-like Receptor (NLR) (7) Notch (10) Nuclear Factor of activated T Cells (NFAT) (8) Nuclear Hormone Receptor 4A/NR4A (2) Nucleoside Antimetabolite/Analog (91) Nucleoside Transporters (1) OAT (3) OGA (1) Opioid Receptor (35) Orexin Receptor (OX Receptor) (40) Organoid (3) Orthopoxvirus (18) Oxidative Phosphorylation (1) Oxytocin Receptor (8) P-glycoprotein (35) P2X Receptor (18) P2Y Receptor (22) p38 MAPK (35) p62 (1) p97 (2) PACAP Receptor (1) PAK (8) Parasite (127) PARP (11) PCSK9 (3) PD-1/PD-L1 (5) PDGFR (41) PDK-1 (3) Penicillin-binding protein (PBP) (2) PERK (9) PGC-1α (1) Phosphatase (28) Phosphodiesterase (PDE) (45) Phospholipase (11) Phosphorylase (1) Photosensitizer (1) Phytohormone (1) PI3K (33) Pim (2) PIN1 (1) PINK1/Parkin (1) PKA (12) PKC (21) Platelet-activating Factor Receptor (PAFR) (4) Polo-like Kinase (PLK) (1) Potassium Channel (57) PPAR (40) Prion Protein (1) Progesterone Receptor (30) Prostaglandin Receptor (56) PROTAC Linkers (29) PROTACs (52) Protease Activated Receptor (PAR) (3) Proteasome (4) Protein Prenyltransferase (1) Proton Pump (32) Protoporphyrinogen IX oxidase (2) PSMA (2) PTHR (1) Pyk2 (2) Pyroptosis (3) Pyruvate Kinase (8) Quinone Reductase (2) RABV (1) RAD51 (2) Radionuclide-Drug Conjugates (RDCs) (1) Raf (13) RAR/RXR (20) Ras (25) Reactive Oxygen Species (ROS) (91) Reference Standards (40) Renin (2) RET (15) Reverse Transcriptase (30) RIP kinase (6) ROCK (4) ROR (4) ROS Kinase (21) RSV (10) Salt-inducible Kinase (SIK) (1) SARS-CoV (79) Ser/Thr Kinase (3) Ser/Thr Protease (6) Serotonin Transporter (57) SGK (1) SGLT (9) SHP1 (2) SHP2 (2) Sigma Receptor (40) Sirtuin (13) Small Interfering RNA (siRNA) (250) Smo (1) SOD (3) Sodium Channel (67) Somatostatin Receptor (3) SOS1 (1) SphK (1) Src (16) STAT (32) STING (8) Succinate Dehydrogenase (2) SWI/SNF Complex (1) Syk (13) TAM Receptor (11) Taste Receptor (11) Tau Protein (10) TGF-beta/Smad (9) TGF-β Receptor (3) Thrombin (12) Thrombopoietin Receptor (5) Thymidylate Synthase (9) Thyroid Hormone Receptor (13) Tie (3) TMV (1) TNF Receptor (27) Toll-like Receptor (TLR) (30) TOPK (1) Topoisomerase (48) Trace Amine-associated Receptor (TAAR) (1) Transketolase (1) TREM receptor (2) Trk Receptor (28) TRP Channel (37) TSH Receptor (2) Tyrosinase (18) Tyrosine Hydroxylase (2) URAT1 (1) Urotensin Receptor (1) Vasopressin Receptor (19) VD/VDR (25) VEGFR (66) Virus Protease (22) VKOR (2) VSV (1) WDR5 (3) Wee1 (2) Wnt (6) Xanthine Oxidase (8) YAP (3) α-synuclein (9) β-catenin (8) β-glucuronidase (1) γ-secretase (4)
By Research Areas:	Cancer (2394) Cardiovascular Disease (538) Endocrinology (433) Infection (842) Inflammation/Immunology (1017) Metabolic Disease (1020) Neurological Disease (1353)
Click Chemistry:	ADC Synthesis (2) TCO (8) Labeling and Fluorescence Imaging (1) PROTAC Synthesis (3) Azide (43) Alkynes (37)
Oligonucleotides:	miRNA mimics (1) A (6) Nucleosides and their Analogs (27) C (3) Nucleoside Phosphoramidites (2) G (2) Rat Pre-designed siRNA Sets (63) I (1) Phospholipids (1) Antisense Oligonucleotides (5) Cholesterol (1) siRNAs (249) Pegylated Lipids (1) U (6) MicroRNAs (1) Aptamers (2) CpG ODNs (5) Mouse Pre-designed siRNA Sets (60) Cationic Lipids (1) Human Pre-designed siRNA Sets (126)

8140

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

352

Peptides

MCE Kits

130

Inhibitory Antibodies

423

Natural
Products

876

Recombinant Proteins

3889

Isotope-Labeled Compounds

249

Antibodies

Click Chemistry

295

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152581

CB2R antagonist 3	Cannabinoid Receptor	Inflammation/Immunology
CB2R antagonist 3 is a selective antagonist of cannabinoid type 2 receptor (CB2R). CB2R antagonist 3 has high affinity for human CB2R and specific selectivity for CB1R. CB2R antagonist 3 can be combined with CB65 (HY-110047), the activator of CB2R. CB2R antagonist 3 effectively up-regulates the expression of anti-inflammatory cytokines and down-regulates the expression of pro-inflammatory cytokines .

HY-152254

CB2R/FAAH modulator-3	FAAH Cannabinoid Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a *CB2R* agonist and FAAH inhibitor. The K_i values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC₅₀ value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection .

HY-131004

CB2R PAM	Cannabinoid Receptor	Neurological Disease
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain .

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-152251

CB2R/FAAH modulator-1	Cannabinoid Receptor FAAH	Inflammation/Immunology
CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with K_is of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC₅₀ of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production .

HY-152253

CB2R/FAAH modulator-2	FAAH Cannabinoid Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a *CB2R* agonist and FAAH inhibitor. The K_i values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC₅₀ value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection .

HY-152576

CB2R agonist 1	Cannabinoid Receptor	Inflammation/Immunology
CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC₅₀ value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human *CB2R* and *CB1R* respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role .

HY-155967

CB1R/AMPK modulator 1	AMPK Cannabinoid Receptor	Metabolic Disease
CB1R/AMPK modulator 1 (Compound 38-S) is an orally active *CB1R/AMPK* modulator, with an K_i of 0.81 nM and an IC₅₀ of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK. CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity .

HY-100328

CB2R-IN-1	Cannabinoid Receptor	Neurological Disease
CB2R-IN-1 is a potent cannabinoid CB₂ receptor inverse agonist with a K_i of 0.9 nM.

HY-147532

CB2R probe 1	Cannabinoid Receptor	Cancer
CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an K_i of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells .

HY-147559

CB1R Allosteric modulator 2	Cannabinoid Receptor	Others
CB1R Allosteric modulator 2 (compound 18) is a potent *CB1R* allosteric modulator. CB1R Allosteric modulator 2 shows negatively affects the functional activity of orthosteric ligands (NAM) at CB1Rs .

HY-147558

CB1R Allosteric modulator 1	Cannabinoid Receptor	Others
CB1R Allosteric modulator 1 (compound 11) is a potent *CB1R* allosteric modulator. CB1R Allosteric modulator 1 shows negatively affects the functional activity of orthosteric ligands (NAM) at CB1Rs .

HY-155336

CB2R agonist 2	Cannabinoid Receptor	Neurological Disease
CB2R agonist 2 (compound cis-17-para) is a *CB2R* agonist .

HY-75054S1

Abiraterone acetate-d3 CB7630-d<sub>3sub>	Isotope-Labeled Compounds Cytochrome P450	Cancer
Abiraterone acetate-d₃ (CB7630-d₃) is deuterium labeled Abiraterone acetate. Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598) .

HY-150067

CB1R antagonist 1	Cannabinoid Receptor	Metabolic Disease
CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC₅₀ value of 4.2 μM and EC₅₀ value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity .

HY-149644

CB2R agonist 3	Cannabinoid Receptor	Inflammation/Immunology
CB2R agonist 3 is an agonist of cannabinoid receptor 2 (CB2R), with EC₅₀ of 0.37μM that plays an important role in immune system .

HY-150056

CB1R Allosteric modulator 3	Cannabinoid Receptor Arrestin	Neurological Disease
CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC₅₀ values of 0.018 μM and 1.241 μM, respectively .

HY-168997

CB1R agonist 1	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
CB1R agonist 1 (Compound '1350') is a potent full agonist of the cannabinoid-1 receptor (CB1R), with a K_i value of 0.95 nM. CB1R agonist 1 exhibits significant pain-reducing effects in multiple pain models, including acute heat pain, inflammatory pain, and neuropathic pain .

HY-150057

CB1R Allosteric modulator 4	Cannabinoid Receptor	Others
CB1R Allosteric modulator 4 is a positive allosteric modulator of cannabinoid type-1 (CB1R) with good biological activity. CB1R Allosteric modulator 4 inhibits cAMP production and shows robust activity in β-arrestin-2 recruitment .

HY-172409

CB1R antagonist 2	Cannabinoid Receptor p38 MAPK NF-κB	Inflammation/Immunology
CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models .

HY-162083

CB2R/5-HT1AR agonist 1	Cannabinoid Receptor 5-HT Receptor	Neurological Disease
CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the *CB₂* receptor (EC₅₀=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of 5-HT_1A receptor (EC₅₀=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties .

HY-75054S

Abiraterone acetate-d4 CB7630-d<sub>4sub>	Isotope-Labeled Compounds Cytochrome P450	Cancer
Abiraterone acetate-d₄ is the deuterium labeled Abiraterone acetate. Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598).

HY-B0228S10

(R)-3-Hydroxybutanoic acid-13C2 sodium (R)-(-)-3-Hydroxybutanoic acid-¹³C<sub>2sub> sodium; (R)-3-Hydroxybutyric acid-¹³C<sub>2sub> sodium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(R)-3-Hydroxybutanoic acid- ¹³C₂ (sodium) is the ¹³C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[2] .

HY-13593S

Chlorambucil-d8 CB-1348-d<sub>8sub>; WR-139013-d<sub>8sub>	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease ^[2] .

HY-12790

CB1-IN-1 BPRCB1184	Cannabinoid Receptor	Neurological Disease
CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively.

HY-B0454S2

Miconazole-d2 R18134-d<sub>2sub>	Fungal Bacterial Antibiotic	Infection
Miconazole-d₂ is the deuterium labeled Miconazole . Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects ^[2] .

HY-13593S1

Chlorambucil-d8-1 CB-1348-d<sub>8sub>-1; WR-139013-d<sub>8sub>-1	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease ^[2] .

HY-12772S2

(2R,4S)-Hydroxy Itraconazole-d5 (2R,4S)-R-63373-d<sub>5sub>	Drug Metabolite Fungal	Others
(2R,4S)-Hydroxy Itraconazole-d₅ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole .

HY-12772S1

(2R,4S)-Hydroxy Itraconazole-d8 (2R,4S)-R-63373-d<sub>8sub>	Drug Metabolite Fungal Isotope-Labeled Compounds	Others
(2R,4S)-Hydroxy Itraconazole-d₈ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].

HY-155481A

CB2 receptor antagonist 4	Cannabinoid Receptor	Others
CB2 receptor antagonist 4 (compound (R)-1) is a *CB2R*-selective inverse agonist with a K_d value of 39 nM .

HY-103641AS1

(2R)-Octyl-α-hydroxyglutarate-d17 (2R)-Octyl-2-HG-d<sub>17sub>	Isotope-Labeled Compounds Others	Cancer
(2R)-Octyl-α-hydroxyglutarate-d₁₇ ((2R)-Octyl-2-HG-d₁₇) is deuterium labeled (2R)-Octyl-α-hydroxyglutarate (HY-103641). (2R)-Octyl-α-hydroxyglutarate is a modified form of S-isomer 2-Hydroxyglutarate .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-172587

CB1R Allosteric modulator 5	Cannabinoid Receptor	Neurological Disease
CB1R Allosteric modulator 5 (compound 3) is a selective, and blood-brain barrier (BBB) permeable Cannabinoid receptor type 1 allosteric modulator with a pIC₅₀ of 6.89. CB1R Allosteric modulator 5 attenuates both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity .

HY-158207S

(+)-Nebivolol-d4 (S,R,R,R)-Nebivolol-d<sub>4sub>; (S,R,R,R)-R 065824-d<sub>4sub>	Isotope-Labeled Compounds	Others
(S,R,R,R)-Nebivolol-d₄ is deuterium labeled (S,R,R,R)-Nebivolol .

HY-163394

CB2 receptor agonist 6	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
CB2 receptor agonist 6 (compound 70) is an agonist of *CB2R, with EC₅₀* of 162 nM. The IC₅₀ values of CB2 receptor agonist 6 are 4.83 μM for *CB1R* and 0.88 μM for *CB2R*. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease .

HY-N6937S1

(R,R)-Secoisolariciresinol diglucoside-d6 (R,R)-SDG-d<sub>6sub>; (R,R)-LGM2605-d<sub>6sub>	Isotope-Labeled Compounds	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside-d₆ is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells ^[2] .

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-147512

CB1/2 agonist 1	Cannabinoid Receptor	Inflammation/Immunology
CB1/2 agonist 1 is a potent and cross the blood-brain barrier *CB1/2* agonist with EC₅₀s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis .

HY-155481

CB2 receptor antagonist 3	Cannabinoid Receptor	Neurological Disease
CB2 receptor antagonist 3 (compound (S)-1) is an inverse agonist of the cannabinoid receptor CB2R with Kd=39 nM. CB2 receptor antagonist 3 can be used as a tool to synthesize a variety of CB2R probes .

HY-75087S

(R)-Pyrrolidine-2-carboxylic acid-d3 (+)-(R)-Proline-d<sub>3sub>; (R)-(+)-Proline-d<sub>3sub>; (R)-2-Carboxypyrrolidine-d<sub>3sub>; (R)-Proline-d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(R)-Pyrrolidine-2-carboxylic acid-d₃ is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-125784AS

(R)-Viloxazine-d5 hydrochloride (R)-Viloxazin-d<sub>5sub> hydrochloride; (R)-Emovit-d<sub>5sub> hydrochloride	Isotope-Labeled Compounds	Others
(R)-Viloxazine-d5 hydrochloride is the deuterium labeled (R)-Viloxazine hydrochloride .

HY-158187S

R-(+)-Cibenzoline-d4 R-(+)-Cifenline-d<sub>4sub>; R-(+)-Ro 22-7796-d<sub>4sub>	Isotope-Labeled Compounds	Others
R-(+)-Cibenzoline-d₄ (R-(+)-Cifenline-d₄) is deuterium labeled R-(+)-Cibenzoline ((R-(+)-Cifenline) .

HY-B0151S1

Pregnenolone-13C2,d2 3β-Hydroxy-5-pregnen-20-one-¹³C<sub>2sub>,d<sub>2sub>	Isotope-Labeled Compounds Autophagy Cannabinoid Receptor Endogenous Metabolite TRP Channel	Neurological Disease
Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[2] .

HY-B0352BS

(R)-Mirtazapine-d3 (R)-Org3770 d<sub>3sub>; (R)-6-Azamianserin d<sub>3sub>	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
(R)-Mirtazapine-d₃ is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].

HY-N1415S1

β-Caryophyllene-13C,d2 (-)-(E)-Caryophyllene-¹³C,d<sub>2sub>; (−)-β-caryophyllene-¹³C,d<sub>2sub>; (−)-trans-Caryophyllene-¹³C,d<sub>2sub>	Endogenous Metabolite Cannabinoid Receptor Isotope-Labeled Compounds	Cancer
β-Caryophyllene- ¹³C,d₂ is ¹³C and deuterated labeled β-Caryophyllene (HY-N1415). β-Caryophyllene is a CB2 receptor agonist .

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	IGF-1R	Cancer
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-125922S

(22R)-Budesonide-d6 Dexbudesonide-d<sub>6sub>; (22R)-BUD-d<sub>6sub>	Isotope-Labeled Compounds Glucocorticoid Receptor Drug Isomer	Inflammation/Immunology
(22R)-Budesonide-d₆ (Dexbudesonide-d₆) is deuterium labeled (22R)-Budesonide. (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[2] .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[2] .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[2] [4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[2] .

HY-N6937

(R,R)-Secoisolariciresinol diglucoside (R,R)-SDG; (R,R)-LGM2605	Structural Classification Linum usitatissimum Linn. Classification of Application Fields Linaceae Source classification Lignans Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells ^[2] .

HY-125833R

Alpha-Naphthoflavone (Standard)	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[2] .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-N15496

Fusaproliferin FUS	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reactive Oxygen Species (ROS) NO Synthase Interleukin Related TNF Receptor p38 MAPK ERK IKK NF-κB
Fusaproliferin is a sesterterpene mycotoxin isolated from Fusarium solani. Fusaproliferin reverse Lipopolysaccharides (HY-D1056) stimulation and the NF-κB and MAPKs signaling pathways contribute to the anti-inflammatory process. Fusaproliferin exhibits affinity for the TLR4 protein with K_D values of 28.6 μM. Fusaproliferin shows cytotoxicity against pancreatic cancer cell with rapid and sub-micromolar IC₅₀ ^[2].

HY-W011370

Pelargonidin chloride	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Quinone Reductase Reactive Oxygen Species (ROS)
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment ^[2] .

HY-P2274R

Argifin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Parasite
Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

HY-N6937R

(R,R)-Secoisolariciresinol diglucoside (Standard)	Structural Classification Linum usitatissimum Linn. Linaceae Source classification Lignans Phenylpropanoids Plants	Others
(R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells ^[2] .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[2] .

HY-59125

(R,R)-(+)-Hydrobenzoin	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R,R)-(+)-Hydrobenzoin is a chiral vicinal diol and an organic catalyst. (R,R)-(+)-Hydrobenzoin is used in asymmetric catalytic reactions ^[2] .

HY-W015851

(R)-3-Hydroxybutanoic acid sodium 5 Publications Verification (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[2].

HY-N0894A

(3R,5R)-Octahydrocurcumin (3R,5R)-Hexahydrobisdemethoxycurcumin	Structural Classification Source classification Phenols Polyphenols Plants Tacca chantrieri Andre Taccaceae	Drug Metabolite
(3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2 .

HY-W015851R

(R)-3-Hydroxybutanoic acid sodium (Standard) (R)-(-)-3-Hydroxybutanoic acid sodium (Standard); (R)-3-Hydroxybutyric acid sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid (sodium) (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid (sodium). This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].

HY-N13500

(2R,3R)-Glucodistylin	Structural Classification Flavonoids Source classification Rhododendron mucronulatum Turcz. Ericaceae Plants Other Flavonoids	Others
(2R,3R)-Glucodistylin is a flavonoid product that can be isolated from Rhododendron mucronulatum .

HY-W051723R

(R)-3-Hydroxybutanoic acid (Standard) (R)-(-)-3-Hydroxybutanoic acid (Standard); (R)-3-Hydroxybutyric acid (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid. This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2].

HY-W051723

(R)-3-Hydroxybutanoic acid 5 Publications Verification (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid	Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Other Diseases Nervous System Disorder Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones ^[2].

HY-75087

(R)-pyrrolidine-2-carboxylic acid (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms .

HY-N12486A

(3S,8R,9R)-Isofalcarintriol	Structural Classification Natural Products Source classification Umbelliferae Plants Mentha suaveolens Ehrh.	Others
(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	Amyloid-β Apoptosis
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells ^[2] .

HY-75087R

(R)-pyrrolidine-2-carboxylic acid (Standard) (+)-(R)-Proline (Standard); (R)-(+)-Proline (Standard); (R)-2-Carboxypyrrolidine (Standard); (R)-Proline (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-pyrrolidine-2-carboxylic acid. This product is intended for research and analytical applications. (R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms[1].

HY-N2049

20(R)-Notoginsenoside R2	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Source classification Plants Araliaceae	Others
20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng .

HY-N2689

(R)-6',7'-Dihydroxybergamottin (R)-6′,7′-DHB	Structural Classification Natural Products Citrus × aurantium Linnaeus Source classification Rutaceae Plants	Cytochrome P450
(R)-6',7'-Dihydroxybergamottin ((R)-6′,7′-DHB) is a competitive inhibitor of human and rat CYP1A1 activity with K_is of 55 μM and 1.72 μM, respectively. (R)-6',7'-Dihydroxybergamottin has the potential for cancer research .

HY-N13594

(6R,9R)-3-Oxo-α-ionol glucoside	Structural Classification Terpenoids Sesquiterpenes Source classification Rosaceae Plants Rosa rugosa Thunb.	Others
(6R,9R)-3-Oxo-α-ionol glucoside is a natural product .

HY-167705

(R)-7,7'-Dihydrotaiwanin C (R)-1,4-Dihydrotaiwanin C	Structural Classification Source classification Lignans Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu Phenylpropanoids Plants Araliaceae	Others
(R)-7,7'-Dihydrotaiwanin C ((R)-1,4-Dihydrotaiwanin C) is a compound that exhibits significant biological activity.

HY-N11080

Cucurbitacin R	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Cayaponia tayuya Plants	Others
Cucurbitacin R is a cucurbitacin. Cucurbitacin R can be isolated from the roots of Cayaponia tayuya. Cucurbitacin R can be used for the research of pain and inflammation .

HY-N10678

R-30-Hydroxygambogic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Guttiferae Plants Garcinia hanburyi Hook. f.	Others
R-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. R-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC₅₀ values of 2.89 and 1.27 μM for K562/R and K562/S, respectively. R-30-Hydroxygambogic acid can be used for the research of cancer .

HY-N11893

8-C-Glucosyl-(R)-aloesol (R)-Aloesinol	Structural Classification Natural Products Liliaceae Source classification Aloe vera (L.) Burm. f. Plants	Others
8-C-Glucosyl-(R)-aloesol ((R)-Aloesinol) is a bioactive chromone analogue .

HY-77490

(R)-(-)-1,3-Butanediol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-(-)-1,3-Butanediol is the R-enantiomer of 1,3-Butanediol (HY-77490A). (R)-(-)-1,3-Butanediol exhibits anti-diabetic property in rats. (R)-(-)-1,3-Butanediol can be used as flavoring and fragrance agents. (R)-(-)-1,3-Butanediol is used to regulate the metabolism of carbohydrate and lipid. ^[2] .

HY-N9746

(R)-4-Methoxydalbergione	Structural Classification Natural Products Ranunculus repens L. Source classification Ranunculaceae Plants	Parasite
(R)-4-Methoxydalbergione is a urease inhibitor with IC₅₀s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens ^[2].

HY-W015954R

(2R,3R)-Butane-2,3-diol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Calcium Channel Bacterial
(2R,3R)-Butane-2,3-diol (Standard) is the analytical standard of (2R,3R)-Butane-2,3-diol (HY-W015954). This product is intended for research and analytical applications. (2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La ³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases .

HY-N2207

rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan	Structural Classification Classification of Application Fields Source classification Lignans Other Diseases Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields	Others
rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan is a chemical constituent of the fruit of Myristica fragrans.

HY-126050R

(R)-Pantetheine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Endogenous Metabolite
(R)-Pantetheine (Standard) is the analytical standard of (R)-Pantetheine. This product is intended for research and analytical applications. (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity ^[2] .

HY-18733

Lipoic acid 5+ Cited Publications (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Reactive Oxygen Species (ROS) Mitochondrial Metabolism
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-W015954

(2R,3R)-Butane-2,3-diol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Calcium Channel Bacterial
(2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La ³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases .

HY-W087952

(R)-(-)-2-Butanol	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Drug Intermediate
(R)-(-)-2-Butanol is the isomer of 2-Butanol, which is found in the females of the white grub beetle, Dasylepida ishigakiensis, to attract males. (R)-(-)-2-Butanol is an intermediate of pharmaceutical synthesis by coupling ^[2] .

HY-N12128

Ophiopogonin R	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides	Others
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Source classification Pelargonium hortorum Plants Endogenous metabolite Geraniaceae Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products ^[2] .

HY-Z0031R

(R)-(-)-1,2-Propanediol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
(R)-(-)-1,2-Propanediol (Standard) is the analytical standard of (R)-(-)-1,2-Propanediol. This product is intended for research and analytical applications. (R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes[1].

HY-N0615R

Notoginsenoside R1 (Standard)	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Source classification Plants Araliaceae	Amyloid-β Apoptosis
Notoginsenoside R1 (Standard) is the analytical standard of Notoginsenoside R1. This product is intended for research and analytical applications. Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells ^[2] .

HY-126050

(R)-Pantetheine Pantetheine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity ^[2] .

HY-N1376

(20R)-Ginsenoside Rg3 4 Publications Verification (20R)-Propanaxadiol; R-ginsenoside Rg3	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Others
(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

HY-N7321A

(R)-Eucomol	Infection other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Bacterial
(R)-Eucomol, a flavonoid derivative, displays marginal antibacterial activity. (R)-Eucomol shows cytotoxic activity against KB and P-388 cells .

HY-N10672

Kuguacin R	Triterpenes Source classification Cucurbitaceae Plants Momordica charantia Linn.	Antibiotic
Kuguacin R is a cucurbitane-type triterpenoid that can be extracted from Momordica charantia L. Kuguacin R possess anti-inflammatory, antimicrobial and anti-viral activities .

HY-N9863

(7R,8R)-Dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside	Structural Classification Source classification Lignans Phenylpropanoids Plants Lysimachia clethroides Duby Primulaceae	Others
(7R,8R)-Dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside is a Lignans product that can be isolated from the herbs of Lysimachia clethroides .

Cat. No.	Product Name	Chemical Structure

HY-B0228S10

(R)-3-Hydroxybutanoic acid-13C2 sodium
(R)-3-Hydroxybutanoic acid- ¹³C₂ (sodium) is the ¹³C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[2] .

HY-12772S2

(2R,4S)-Hydroxy Itraconazole-d5
(2R,4S)-Hydroxy Itraconazole-d₅ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole .

HY-75054S1

Abiraterone acetate-d3
Abiraterone acetate-d₃ (CB7630-d₃) is deuterium labeled Abiraterone acetate. Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598) .

HY-75054S

Abiraterone acetate-d4
Abiraterone acetate-d₄ is the deuterium labeled Abiraterone acetate. Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598).

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease ^[2] .

HY-B0454S2

Miconazole-d2
Miconazole-d₂ is the deuterium labeled Miconazole . Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects ^[2] .

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease ^[2] .

HY-12772S1

(2R,4S)-Hydroxy Itraconazole-d8
(2R,4S)-Hydroxy Itraconazole-d₈ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].

HY-103641AS1

(2R)-Octyl-α-hydroxyglutarate-d17
(2R)-Octyl-α-hydroxyglutarate-d₁₇ ((2R)-Octyl-2-HG-d₁₇) is deuterium labeled (2R)-Octyl-α-hydroxyglutarate (HY-103641). (2R)-Octyl-α-hydroxyglutarate is a modified form of S-isomer 2-Hydroxyglutarate .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-158207S

(+)-Nebivolol-d4
(S,R,R,R)-Nebivolol-d₄ is deuterium labeled (S,R,R,R)-Nebivolol .

HY-N6937S1

(R,R)-Secoisolariciresinol diglucoside-d6

(R,R)-Secoisolariciresinol diglucoside-d₆ is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells ^[2] .

HY-75087S

(R)-Pyrrolidine-2-carboxylic acid-d3
(R)-Pyrrolidine-2-carboxylic acid-d₃ is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-125784AS

(R)-Viloxazine-d5 hydrochloride
(R)-Viloxazine-d5 hydrochloride is the deuterium labeled (R)-Viloxazine hydrochloride .

HY-158187S

R-(+)-Cibenzoline-d4
R-(+)-Cibenzoline-d₄ (R-(+)-Cifenline-d₄) is deuterium labeled R-(+)-Cibenzoline ((R-(+)-Cifenline) .

HY-B0151S1

Pregnenolone-13C2,d2

Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[2] .

HY-B0352BS

(R)-Mirtazapine-d3
(R)-Mirtazapine-d₃ is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].

HY-N1415S1

β-Caryophyllene-13C,d2
β-Caryophyllene- ¹³C,d₂ is ¹³C and deuterated labeled β-Caryophyllene (HY-N1415). β-Caryophyllene is a CB2 receptor agonist .

HY-125922S

(22R)-Budesonide-d6
(22R)-Budesonide-d₆ (Dexbudesonide-d₆) is deuterium labeled (22R)-Budesonide. (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity .

HY-78131BS

(R)-(-)-Ibuprofen-d3
(R)-(-)-Ibuprofen-d₃ is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-135336S

(R)-Verapamil-d7 hydrochloride
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents ^[2].

HY-B0006CS

(R)-Carvedilol-d4
(R)-Carvedilol-d₄ is deuterium labeled (R)-Carvedilol. (R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX) .

HY-17496S

(R)-Timolol-d9 maleate
(R)-Timolol-d₉ (maleate) is deuterium labeled (R)-Timolol (maleate).

HY-N0221S

Daurisoline-d2
Daurisoline-d₂ is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer ^[2].

HY-13331S1

Clascoterone-d6
Clascoterone-d₆ (Cortexolone 17 alpha-propionate-d₆) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist .

HY-110189S

Pregnenolone monosulfate sodium-13C2,d2

Pregnenolone monosulfate (sodium)- ¹³C₂,d₂ is the ¹³C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication ^[2]. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B0105BS

(-)-Ketoconazole-d3
(-)-Ketoconazole-d₃ is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).

HY-W021425S1

D-Mannosamine-d2 hydrochloride
D-Mannosamine-d₂ (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal-d₂) hydrochloride is a deuterium labeled D-Mannosamine hydrochloride (HY-W021425). D-Mannosamine is a six-carbon glycoamine that is an amino derivative of D-mannose. D-mannoamine plays a variety of important biological roles in cells.

HY-18733S

Lipoic acid-d4
Lipoic acid-d₄ ((R)-(+)-α-Lipoic acid-d₄) is deuterium labeled Lipoic acid. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid .

HY-13956A

(R)-Pioglitazone-d1
(R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities.

HY-W011090S

((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-13C9,15N3 sodium
((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate- ¹³C₉, ¹⁵N₃ (sodium) is the ¹³C and ¹⁵N labeled Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate .

HY-117068S

(R)-Bromoenol lactone-d7
(R)-Bromoenol lactone-d₇ ((R,E)-Bromoenol lactone-d₇) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC₅₀ of approximately 0.6 μM ^[2].

HY-B0105S1

Ketoconazole-d4
Ketoconazole-d₄ is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

HY-W015851S2

(R)-3-Hydroxybutanoic acid-13C4 sodium
(R)-3-Hydroxybutanoic acid- ¹³C₄ sodium is a ¹³C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[2].

HY-B0267CS

(R)-Oxybutynin-d10

(R)-Oxybutynin-d₁₀ (Aroxybutynin-d₁₀) is deuterium labeled (R)-Oxybutynin. (R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction ^[2] .

HY-13662BS

(R)-Lansoprazole-d4
(R)-Lansoprazole-d₄ is deuterium labeled (R)-Lansoprazole. (R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) ^[2].

HY-B0389S26

D-Glucose-d2-2
D-Glucose-d₂-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol

HY-13331S2

Clascoterone-d5-1
Clascoterone-d₅-1 (Cortexolone 17 alpha-propionate-d₅-1) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist .

HY-14149S

Cisapride-d6
Cisapride-d₆ (R51619-d₆) is deuterium labeled Cisapride. Cisapride (R 51619) is an orally active 5-HT₄ receptor agonist with an EC₅₀ value of 140 nM. Cisapride is a hERG blocker with an IC₅₀ value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity ^[2] .

HY-125527AS

17(R)-Resolvin D1-d5
17(R)-Resolvin D1-d₅ (17(R)-RvD1-d₅) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy ^[2].

HY-30237S

(R)-Roscovitine-d7
(R)-Roscovitine-d₇ (Seliciclib-d₇; CYC202-d₇) is deuterium-labeled (R)-Roscovitine (HY-30237) .

HY-12772S3

Hydroxy Itraconazole-d6
Hydroxy Itraconazole-d₆ (R-63373-d₆) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-12515CS1

(R)-Nicardipine-d3
(R)-Nicardipine-d₃ is the deuterium labeled R-Nicardipine (HY-12515C) .

HY-B0411S2

Domperidone-13C6
Domperidone- ¹³C₆ (R33812- ¹³C₆) is ¹³C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .

HY-116969S

22(R)-Hydroxycholesterol-d7
22(R)-Hydroxycholesterol-d₇ is deuterium labeled 22(R)-Hydroxycholesterol.

HY-Y0418S4

Dulcite-d2
Dulcite-d₂ is the deuterium labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact ^[2].

HY-144856S1

Sapropterin-d3
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) ^[2].

HY-157075S

(Z)-Rilpivirine-d4
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-B0814S1

Levocetirizine-d4

Levocetirizine-d₄ ((R)-Cetirizine-d₄) is the deuterium-labeled Levocetirizine (HY-B0814) . Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria ^[2].

HY-B1470S

Azaperone-d4
Azaperone-d₄ is the deuterium labeled Azaperone. Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks