IL-31R alpha Protein, Cynomolgus (HEK293, His)

IL-31R alpha Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-31R alpha protein, expressed by HEK293, with C-His tag.

The IL-31R alpha protein plays a crucial role in immune response, as it forms the interleukin-31 receptor by associating with OSMR. This receptor activates STAT3, and to a lesser extent, STAT1 and STAT5. It is believed to be involved in skin immunity and mediates IL31-induced itch, potentially relying on cation channels TRPA1 and TRPV1. Additionally, IL-31R alpha positively regulates the numbers and cycling status of immature subsets of myeloid progenitor cells in the bone marrow, both in vivo and in vitro, enhancing myeloid progenitor cell survival. It forms a heterodimer with OSMR and interacts with JAK1 and STAT3.

Cynomolgus

HEK293

C-8*His

XP_045249656.2 (A20-E519)

102117994

Partial

ALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTAKRTYAFGKKHDNCTTSSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSDMTCWRLEDIAKTEPPEIFSVKPVLGIKRMIQIEWIKPELAPVSSDLKYALRFRTVNSTSWMEVNFAKNRKDTNQTYNLMGLAFTEYVVALRCAVKESKFWSDWSREKMGMTEEEAPCGLELWRVLKPTEVDGRRPVRLLWKKARGAPVLEKTLGYNIWYFPENNTNLTETVNTTNQQLELHLGGESYWVSMISYNSLGKSPVTTLRIPAIQEKSFRCIEVMQACLAEDQLVVKWQSSALDVNTWMIEWFPDMDSEHPTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGIPSKGPETKVENIGVKTVTITWKDIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYTVRVMASTSAGGINGTSINFKTLSFSVFE

Approximately 90-120 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.