IL-31R alpha Protein, Human (HEK293, His)

IL-31R alpha protein binds to IgM heavy and light chains and helps IgM assembly and secretion. It can act as a molecular chaperone or an oxidoreductase, exhibiting low oxidoreductase activity. IL-31R alpha Protein, Human (HEK293, His) is the recombinant human-derived IL-31R alpha protein, expressed by HEK293 , with C-His labeled tag.

MZB1/PERP1 associates with immunoglobulin M (IgM) heavy and light chains, facilitating IgM assembly and secretion. It may function as a molecular chaperone or oxidoreductase, as it exhibits a low level of oxidoreductase activity. Additionally, isoform 2 may play a role in apoptosis regulation. MZB1/PERP1 contributes to the diversification of peripheral B-cell functions by modulating Ca(2+) stores, antibody secretion, and integrin activation. Furthermore, it acts as a hormone-regulated adipokine/pro-inflammatory cytokine implicated in chronic inflammation, affecting cellular expansion and attenuating insulin response in adipocytes, potentially playing a role in the onset of insulin resistance.

1.Immobilized human IL31RA-His at 2 μg/mL (100 μl/well) can bind biotinylated cynomolgus IL31h , The EC₅₀ of biotinylated cynomolgus IL31h is 15-60 ng/mL.
2.Immobilized Recombinant Human Interleukin-31 receptor A / IL31RA Protein (His Tag) at 2 μg/mL (100 μL/well) can bind IL31-His/Biotin , the EC₅₀ is 12-36 ng/mL.

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  Loaded Nemolizumab (HY-P99162) on AHC2 biosensor, can bind IL-31R alpha Protein, Human (HEK293, His) with an affinity constant of 1.825E-09 M as determined in BLI assay.

Human

HEK293

C-His

Q8NI17-1/EAW54932.1 (A20-S516)

133396  [NCBI]

Extracellular Domain

Approximately 58.2 kDa

Greater than 85% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.