CXCR3 Antibody (YA3426)

CXCR3 Antibody is an unconjugated, approximately 41 kDa, rabbit-derived, anti-CXCR3 monoclonal antibody. CXCR3 Antibody can be used for: WB expriments in human background without labeling.

CD183 is a receptor for the C-X-C chemokines CXCL9, CXCL10, and CXCL11, mediating the proliferation, survival, and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). It also binds CCL21 and likely promotes cell chemotaxis. Upon activation by PF4, it induces migration of activated T-lymphocytes via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Additionally, CD183 serves as a receptor for CXCL4 and mediates the inhibitory effects of CXCL9, CXCL10, and CXCL11 on the proliferation, survival, and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated pathway (PubMed:12782716), though it does not promote chemotaxis. Interaction with CXCL4 or CXCL10 activates the p38MAPK pathway, contributing to angiogenesis inhibition. Overexpression in renal cancer cells downregulates the anti-apoptotic protein HMOX1 and promotes apoptosis. CD183 also mediates the activity of CXCL11.

P49682

Predicted band size: 41kDa;Observed band size: 45kDa

affinity purified

Non-conjugated

Unmodified

AB_3676579

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human

WB: 1/500-1/1000; IF: 1/50-1/200; IP: 1/50

WB, ICC/IF, IP

Liquid

Supplied in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human CXCR3.