IL1RAPL1 Antibody (YA4538)

IL1RAPL1 Antibody (YA4538) is a mouse-derived and non-conjugated IgG1 antibody, targeting to IL1RAPL1. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

IL1RAPL1 Protein emerges as a multifaceted regulator, potentially influencing secretion and presynaptic differentiation by inhibiting the activity of the N-type voltage-gated calcium channel. Additionally, it may activate the MAP kinase JNK, indicating its potential involvement in intracellular signaling pathways. IL1RAPL1 is implicated in neurite outgrowth, emphasizing its role in neuronal development. Remarkably, during dendritic spine formation, IL1RAPL1 demonstrates bidirectional capabilities, inducing both pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD. The diverse functional roles proposed for IL1RAPL1 underscore its significance in orchestrating complex cellular processes associated with synaptic function, neuronal development, and intracellular signaling pathways, warranting further exploration into its precise molecular mechanisms and broader implications in neuronal biology.

Q9NZN1

Predicted band size: 80 kDa; Observed band size: 80 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human IL1RAPL1 (AA: 541-694) expressed in E. Coli.