2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. LEI-101

LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC50 of 8 for hCB2, and a pKi of less than 4 for hERG. LEI-101 is ~100-fold more potent in binding to CB2 receptors than to CB1 receptors.

For research use only. We do not sell to patients.

LEI-101 Chemical Structure

LEI-101 Chemical Structure

CAS No. : 2250025-91-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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LEI-101 Related Antibodies

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CB1 CB2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC50 of 8 for hCB2, and a pKi of less than 4 for hERG. LEI-101 is ~100-fold more potent in binding to CB2 receptors than to CB1 receptors[1][2].

In Vivo

LEI-101 (2, 6, and 20 mg/kg, po) shows in vivo activity in a spinal nerve ligation model of neuropathic pain in rats[1].
LEI-101 (p.o. or i.p.) at 3 or 10 mg/kg dose-dependently prevents kidney dysfunction and/or morphological damage induced by cisplatin in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neuropathy-induced mechanical allodynia in male wistar rats[1].
Dosage: 2, 6, and 20 mg/kg.
Administration: PO, single dose.
Result: Induced a dose-dependent antinociceptive effect after 2 h of dosing.
Animal Model: Fed male Wistar rats[1].
Dosage: 1 mg/kg iv and 5 mg/kg po (Pharmacological Analysis).
Administration: IV and PO.
Result: Exhibited T1/2 of 1.7 h and 0.8 h for po and iv administration.
Had a low clearance and 100% oral bioavailability.
Molecular Weight

508.99

Formula

C23H26ClFN4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2CC2)C(CN1CC3=CC=C(C4=NC(CN5CCS(CC5)(=O)=O)=C(F)C=C4)C=C3)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (229.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9647 mL 9.8234 mL 19.6468 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9647 mL 9.8234 mL 19.6468 mL 49.1169 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL 9.8234 mL
10 mM 0.1965 mL 0.9823 mL 1.9647 mL 4.9117 mL
15 mM 0.1310 mL 0.6549 mL 1.3098 mL 3.2745 mL
20 mM 0.0982 mL 0.4912 mL 0.9823 mL 2.4558 mL
25 mM 0.0786 mL 0.3929 mL 0.7859 mL 1.9647 mL
30 mM 0.0655 mL 0.3274 mL 0.6549 mL 1.6372 mL
40 mM 0.0491 mL 0.2456 mL 0.4912 mL 1.2279 mL
50 mM 0.0393 mL 0.1965 mL 0.3929 mL 0.9823 mL
60 mM 0.0327 mL 0.1637 mL 0.3274 mL 0.8186 mL
80 mM 0.0246 mL 0.1228 mL 0.2456 mL 0.6140 mL
100 mM 0.0196 mL 0.0982 mL 0.1965 mL 0.4912 mL
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LEI-101 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LEI-1012250025-91-1LEI101LEI 101Cannabinoid ReceptorkidneydysfunctionneuropathicpainInhibitorinhibitorinhibit

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