PPP1R1A Protein, Human (His)

PPP1R1A Protein, Human (His) is the recombinant human-derived PPP1R1A protein, expressed by E. coli, with C-6*His labeled tag.

Protein phosphatase 1 regulatory subunit 1A is a potent inhibitor of protein phosphatase 1 (PP1). PPP1R1A plays an important role in the hormonal control of glycogen metabolism. Hormones that raise intracellular cAMP increase I-1 activity in many tissues. I-1 activation may enable cAMP to control proteins that are not directly phosphorylated by PKA. As intracellular calcium rises, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type 2 phosphatase. PPP1R1A may regulate activation of PI3K-Akt pathway, cell cycle, glycogen metabolism, and recruitment of M2 macrophages in liver cancer. PPP1R1A regulates GLR1R-mediated expansion of glucose-stimulated insulin secretion in beta cells. Inhibition of PKA/PPP1R1A/PP1 pathway has potential therapeutic value in the treatment of both primary and metastatic Ewing's sarcoma (ES)^[1][2][3][4].

Human

E. coli

C-6*His

AAH22470.1 (M1-V171)

5502  [NCBI]

Full Length

MEQDNSPQKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

Approximately 18 kDa,based on SDS-PAGE under reducing conditions.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.