2. Immunology/Inflammation
  3. LAG-3
  4. Anti-Mouse FGL-1 Antibody (177R4)

Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1 IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8+ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer.

For research use only. We do not sell to patients.

Anti-Mouse FGL-1 Antibody (177R4)

Anti-Mouse FGL-1 Antibody (177R4) Chemical Structure

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Description

Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1 IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8+ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer[1][2].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

FGL-1
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse FGL-1 Antibody (177R4) Related Antibodies
In Vivo

Anti-Mouse FGL-1 Antibody (177R4) (100 μg, i.p., on day 1, 3, 6, 12, 15 and 18) significantly inhibits tumor growth combined with PD-1 mAb in C57BL/6J mice bearing Lewis lung carcinoma (LLC) tumors[1].
Anti-Mouse FGL-1 Antibody (177R4) (100 μg, i.p., on day 6, 10, 14 and 18) significantly inhibit tumor growth combined with PD-1 mAb in female C57BL/6J mice bearing MB49 tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×106 LLC cells injected C57BL/6J mice (4-6 weeks)[1]
Dosage: 100 μg, combined with PD-1 mAb (100 μg)
Administration: Intraperitoneal injection (i.p.), on day 1, 3, 6, 12, 15 and 18
Result: Significantly inhibited tumor volume.
Increased CD8+ T cell infiltration within the tumor.
Increased the expression of IFN-γ, TNF-α, and Perforin.
Reduced Ki67 positive cells.
Animal Model: 1×105 MB49 cells injected female C57BL/6J mice (6-8 weeks)[2]
Dosage: 100 μg, combined with PD-1 mAb (100 μg)
Administration: Intraperitoneal injection (i.p.), on day 6, 10, 14 and 18
Result: Significantly inhibited tumor volume and weight.
Significantly increased infiltration of CD8 T cells.
Gene ID

234199  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse FGL-1 Antibody (177R4)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse FGL-1 Antibody (177R4) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse FGL-1 Antibody (177R4)LAG-3Lymphocyte activation gene-3CD223FGL-1T cellCD8LLCMB49Inhibitorinhibitorinhibit

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Anti-Mouse FGL-1 Antibody (177R4)
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