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  4. CXCR3 Antibody (YA4052)

CXCR3 Antibody (YA4052)

Cat. No.: HY-P84355
COA User Guide for Antibodies Technical Support

CXCR3 Antibody (YA4052) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD183. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

CXCR3 Antibody (YA4052) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD183. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

Background

CD183 is a receptor for the C-X-C chemokines CXCL9, CXCL10, and CXCL11, mediating the proliferation, survival, and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). It also binds CCL21 and likely promotes cell chemotaxis. Upon activation by PF4, it induces migration of activated T-lymphocytes via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Additionally, CD183 serves as a receptor for CXCL4 and mediates the inhibitory effects of CXCL9, CXCL10, and CXCL11 on the proliferation, survival, and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated pathway (PubMed:12782716), though it does not promote chemotaxis. Interaction with CXCL4 or CXCL10 activates the p38MAPK pathway, contributing to angiogenesis inhibition. Overexpression in renal cancer cells downregulates the anti-apoptotic protein HMOX1 and promotes apoptosis. CD183 also mediates the activity of CXCL11.

Gene ID
SwissProt ID
Synonyms
CXCR3; GPR9; MigR; CD182; Mig-R; CKR-L2; CMKAR3; IP10-R
Molecular Weight

Predicted band size: 40.7 kDa; Observed band size: 50 kDa

Purity

affinity purified.

Conjugation

Non-conjugated

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Host

Mouse

Reactivity

Human

Dilution Ratio

WB: 1/500-1/2000; IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

Application

WB, IHC-P, FC, ELISA

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG1

Immunogen

Purified recombinant fragment of human CD183 (AA: extra mix) expressed in E. Coli.

Documentation

CXCR3 Antibody (YA4052) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CXCR3 Antibody (YA4052)
Cat. No.:
HY-P84355
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