GCGR/Glucagon receptor Protein, Mouse (HEK293, Fc)

GCGR/glucagon receptor protein is a G protein-coupled receptor for glucagon that centrally regulates blood glucose levels. It plays a key role in the fasting response by actively regulating hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. GCGR/Glucagon receptor Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GCGR/Glucagon receptor protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GCGR/Glucagon receptor Protein, Mouse (HEK293, Fc) is 111 a.a., with molecular weight of 50-65 kDa.

The GCGR/Glucagon receptor Protein serves as a G-protein coupled receptor for glucagon, playing a central role in the regulation of blood glucose levels and glucose homeostasis. It actively regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis, making it a key mediator of responses to fasting. Upon ligand binding, the receptor undergoes a conformational change that initiates signaling via guanine nucleotide-binding proteins (G proteins), subsequently modulating the activity of downstream effectors such as adenylate cyclase. This modulation results in the promotion of adenylate cyclase activation. Additionally, the receptor contributes to signaling via a phosphatidylinositol-calcium second messenger system, further emphasizing its multifaceted role in glucose regulation.

Mouse

HEK293

C-hFc

Q61606 (A27-K137)

14527  [NCBI]

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.