kappa Opioid Receptor Antibody (YA3132)

kappa Opioid Receptor Antibody (YA3132) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3132), targeting kappa Opioid Receptor, with a predicted molecular weight of 43 kDa (observed band size: 60 kDa). kappa Opioid Receptor Antibody (YA3132) can be used for WB, IP experiment in rat background.

The kappa Opioid Receptor is a G-protein coupled opioid receptor that primarily serves as a receptor for endogenous alpha-neoendorphins and dynorphins, but exhibits low affinity for beta-endorphins. It also binds various synthetic opioids and the psychoactive diterpene salvinorin A. Ligand binding induces a conformational change, triggering signaling via guanine nucleotide-binding proteins (G proteins) and modulating downstream effectors such as adenylate cyclase, ultimately inhibiting its activity. This receptor suppresses neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, playing a role in pain perception. Additionally, it mediates reduced physical activity upon synthetic opioid treatment and regulates salivation in response to such opioids. It may also be involved in arousal and the regulation of autonomic and neuroendocrine functions.

P33534

Predicted band size: 43 kDa; Observed band size: 60 kDa

Affinity Purified

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Rat

WB: 1/500-1/1000;IP: 1/20

WB, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of mouse Kappa Opioid Receptor