2. Gene
  3. Oprk1 - opioid receptor, kappa 1 Gene

Oprk1 - opioid receptor, kappa 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1

Gene ID: 18387 | Gene type: protein coding

About Oprk1

Summary

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Oprk1 Products(3)

mRNA Protein Name
NM_001204371.1 NP_001191300.1 kappa-type opioid receptor isoform 1
NM_001318735.1 NP_001305664.1 kappa-type opioid receptor isoform 1x
NM_011011.2 NP_035141.1 kappa-type opioid receptor isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled opioid receptor activity IDA
IDA: Inferred from direct assay
9463367 MGI
enables G protein-coupled opioid receptor activity IMP
IMP: Inferred from mutant phenotype
26635353 MGI
Biological Process GO Annotation Evidence Reference Source
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
9463367 MGI
involved in regulation of saliva secretion IMP
IMP: Inferred from mutant phenotype
9463367 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
9463367 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
9463367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kappa-type opioid receptor

opioid receptor, kappa 2

Oprk1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83387 kappa Opioid Receptor Antibody (YA3132) WB, IP Rat

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-116163 ML350 / Unkown
HY-RS09802 OPRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21006 Oprk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27523 Oprk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oprk1 NCBI NCBI:4986