PI3 Kinase p85 alpha Antibody (YA3930)

PI3 Kinase p85 alpha Antibody (YA3930) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PIK3R1. It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse.

PI 3 Kinase p85 alpha binds to activated (phosphorylated) protein-Tyr kinases via its SH2 domain, acting as an adapter to mediate the association of the p110 catalytic unit with the plasma membrane. It is essential for insulin-stimulated increases in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Additionally, it plays a significant role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA, and PDGFRB, as well as in ITGB2 signaling. Similarly, it modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in an ER stress- and/or insulin-dependent manner during metabolic overloading in the liver, thereby contributing to improved glucose tolerance.

P27986

Predicted band size: 84 kDa; Observed band size: 84 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse

IHC: 1/200-1/1000; IF: 1/100; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human PIK3R1 (AA: 159-388) expressed in E. Coli.