2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Pellotine

Pellotine is an alkaloid that can be isolated from Lophophora. Pellotine is the inverse agonist for 5-HT7 receptor with an EC50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with Ki of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release.

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Pellotine Chemical Structure

Pellotine Chemical Structure

CAS No. : 19622-05-0

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Pellotine Related Antibodies

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Description

Pellotine is an alkaloid that can be isolated from Lophophora. Pellotine is the inverse agonist for 5-HT7 receptor with an EC50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with Ki of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release[1].

IC50 & Target

5-HT7 Receptor

 

Human 5-HT7 Receptor

291 nM (EC50)

5-HT1D Receptor

117 nM (Ki)

5-HT6 Receptor

170 nM (Ki)

Molecular Weight

237.29

Formula

C13H19NO3
CAS No.
SMILES

COC1=C(OC)C(O)=C(C(C)N(C)CC2)C2=C1
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Purity & Documentation
References
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Pellotine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pellotine19622-05-05-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorinverse agonistneuronal excitabilityInhibitorinhibitorinhibit

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