2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-1R Antibody (JAMA-147)

Anti-Mouse IL-1R Antibody (JAMA-147) 

Cat. No.: HY-P99140 Purity: 95.00%
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Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster.Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic Disease and infection, such as diabetes.

For research use only. We do not sell to patients.

Anti-Mouse IL-1R Antibody (JAMA-147) Chemical Structure

Anti-Mouse IL-1R Antibody (JAMA-147) Chemical Structure

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Description

Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster.Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic Disease and infection, such as diabetes[1][2][3][4].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
IC50 & Target

IL-1

 

In Vitro

Anti-Mouse IL-1R Antibody (JAMA-147) (10 μg/mL, 3 days) significantly diminishes Spp1hi-TAM-mediated T cell suppression in CD8+ T cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-1R Antibody (JAMA-147) Related Antibodies
In Vivo

Anti-Mouse IL-1R Antibody (JAMA-147) (200 µg/dose, i.p., every 3 days from day 14 to 28) decreases the IL-17+ Treg cell ratio and alleviates the T17/Treg imbalance in experimental autoimmune prostatitis (EAP) mouse models[1].
Anti-Mouse IL-1R Antibody (JAMA-147) (50 μg/kg, i.p., daily for 4 weeks) improves IFNAR signaling in late prediabetic 8-to 10-week-old NOD (non-obese diabetic) mice models[3].
Anti-Mouse IL-1R Antibody (JAMA-147) (40 mg/kg, i.p.) enhances NMEC (neonatal meningitis-causing Escherichia coli) RS218 colonization of the brain, blood and other tissues in NOS2-/- mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Experimental autoimmune prostatitis (EAP) mice models (NOD, male, 5 weeks)[1]
Dosage: 200 µg/dose
Administration: Intraperitoneally injection, every 3 days from day 14 to 28
Result: Decreased T17 cells and 17+Treg cells and increased Treg cells.
Animal Model: NOD (non-obese diabetic) mice models (female, 8-10 weeks)[3]
Dosage: 50 μg/kg
Administration: Intraperitoneally injection, daily for 4 weeks
Result: Increased expression of tonic-sensitive Irf7, Ifit1, Mx1, Stat1, and Stat2 in the spleen.
Gene ID

16177  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-1R Antibody (JAMA-147)]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-1R Antibody (JAMA-147) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-1R Antibody (JAMA-147)Interleukin RelatedILIL-1Spp1hi-TAMT cellinflammationdiabetesEAPNMEC RS218Inhibitorinhibitorinhibit

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