2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. Cixutumumab

Cixutumumab  (Synonyms: IMC-A12; NSC742460)

Cat. No.: HY-P99189 Purity: 99.63%
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Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer.

For research use only. We do not sell to patients.

CAS No. : 947687-12-9

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Based on 1 publication(s) in Google Scholar

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Description

Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer[1].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
IC50 & Target

IGF1R/CD221
In Vitro

Cixutumumab (IMC-A12) (0.01-100 nM; 96 h) exhibits at least 50% growth inhibition in CHLA-9, TC-71and Rh41 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cixutumumab Related Antibodies

Cell Viability Assay[1]

Cell Line: CHLA-9, TC-71, Rh41 cells
Concentration: 0.01-100 nM
Incubation Time: 96 h
Result: Inhibited CHLA-9, TC-71and Rh41 cells growth with IC50 values of 49.31, 0.66 and 0.04 nM, respectively.
In Vivo

Cixutumumab (IMC-A12) (1 mg/rat; i.p.; twice weekly for 6 weeks) shows broad-spectrum antitumor activity, inhibits tumor growth of the PPTP’s in vivo solid tumor panels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB17SC-M scid-/- female mice (solid tumor xenografts model)[1].
Dosage: 1 mg/rat
Administration: Intraperitoneal injection; twice weekly for 6 weeks.
Result: Demonstrated broad antitumor activity against the PPTP’s in vivo solid tumor panels, with the activity primarily being tumor growth inhibition rather than tumor regression.
Clinical Trial
Gene ID

3480  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Cixutumumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized IGF-I R Protein, Human can bind Cixutumumab. The EC50 for this effect is 2.853 ng/mL.
Purity & Documentation
References
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Cixutumumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cixutumumab947687-12-9IMC-A12 NSC742460NSC742460NSC 742460NSC-742460IGF-1RInsulin-like growth factor-1 receptorCHLA-9TC-71Rh41cancerprostate cancermalignancieslung cancerInhibitorinhibitorinhibit

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