2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-21R Antibody (4A9)

Anti-Mouse IL-21R Antibody (4A9) 

Cat. No.: HY-P990218 Purity: 95.00%
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Anti-Mouse IL-21R Antibody (4A9) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-21R. Anti-Mouse IL-21R Antibody (4A9) blocks IL-21 signaling. Anti-Mouse IL-21R Antibody (4A9) can be used for the researches of cancer, infection immunology and inflammation, such as psoriasis, hepatocellular carcinoma and C. rodentium infection.

For research use only. We do not sell to patients.

Anti-Mouse IL-21R Antibody (4A9)

Anti-Mouse IL-21R Antibody (4A9) Chemical Structure

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Description

Anti-Mouse IL-21R Antibody (4A9) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-21R. Anti-Mouse IL-21R Antibody (4A9) blocks IL-21 signaling. Anti-Mouse IL-21R Antibody (4A9) can be used for the researches of cancer, infection immunology and inflammation, such as psoriasis, hepatocellular carcinoma and C. rodentium infection[1][2][3].

IC50 & Target

IL-21R
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-21R Antibody (4A9) Related Antibodies
In Vivo

Anti-Mouse IL-21R Antibody (4A9) (200 μg, i.p., twice a week for 5 weeks) impedes tumor progression in metabolic dysfunction associated steatohepatitis-driven hepatocellular carcinoma mice models[1].
Anti-Mouse IL-21R Antibody (4A9) (25 mg/kg, i.p., every the other day from day 35) suppresses fecal C. rodentium-specific IgA and inhibited bacterial clearance in C. rodentium infected mice models[2].
Anti-Mouse IL-21R Antibody (4A9) (140 μg, i.p., at days -2, 0, 1, 3, and 5 of induction) alleviates imiquimod-induced psoriasis-like skin lesion in imiquimod-induced psoriasis mice models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Metabolic dysfunction associated steatohepatitis-driven hepatocellular carcinoma mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, twice a week for 5 weeks
Result: Signifcantly reduced tumorigenesis, spleen and liver weight.
Reduced cyclin D1 (Ccnd1), antigen identifed by monoclonal antibody Ki67 and cyclin dependent kinase 4.
Dramatically reduced lipid accumulation and triglyceride and cholesterol levels in the serum and tumor tissue.
Enhanced cytotoxic CD8+ T lymphocyte activation.
Had fewer IgA+ B cells.
Animal Model: C. rodentium infected micemodels[2]
Dosage: 25 mg/kg
Administration: Intraperitoneally injection, every the other day from day 35
Result: Decreased GL7+CD95+ GC B cells in PP, and suppressed total IgA+ B cells and B220+CD138−CD38+IgA+ memory B cells in spleen, PP, and LP.
Decreased B220−CD38−CD138+IgA+ plasma cells.
Animal Model: Imiquimod-induced psoriasis mice models[3]
Dosage: 140 μg
Administration: Intraperitoneally injection, at days -2, 0, 1, 3, and 5 of induction
Result: Inhibited epidermal thickening.
Significantly reduced accumulation of MDSCs in skin lesions and splenic Th17 cells.
Gene ID

60504  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-21R Antibody (4A9)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-21R Antibody (4A9) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-21R Antibody (4A9)Interleukin RelatedILIL-21IL-21RCancerHepatocellular carcinomaC. rodentiumPsoriasisInhibitorinhibitorinhibit

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