2. Neuronal Signaling
  3. Serotonin Transporter Dopamine Transporter
  4. iso-WAY-260022

iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats.

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iso-WAY-260022 Chemical Structure

iso-WAY-260022 Chemical Structure

CAS No. : 1214914-38-1

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Description

iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats[1].

Molecular Weight

400.48

Formula

C21H31F3N2O2
CAS No.
SMILES

C[C@H](N[C@@H](C1)C)CN1C[C@@H](C2=CC(OC(F)(F)F)=CC=C2)C3(CCCCC3)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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iso-WAY-260022 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iso-WAY-2600221214914-38-1iso-NRI-022Serotonin TransporterDopamine Transporter5-HTTSERTSLC6A4DATSLC6A3hNEThDAThSERTnorepinephrine reuptakevasomotor symptomsInhibitorinhibitorinhibit

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