Phospho-PDGFR beta (Tyr740) Antibody (YA3062)

Phospho-PDGFR beta (Tyr740) Antibody (YA3062) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3062), targeting Phospho-PDGFR beta (Tyr740), with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). Phospho-PDGFR beta (Tyr740) Antibody (YA3062) can be used for WB, ICC/IF experiment in mouse, rat background.

PDGF Receptor beta is a tyrosine-protein kinase that functions as a cell-surface receptor for homodimeric PDGFB and PDGFD, as well as heterodimers formed by PDGFA and PDGFB. It plays essential roles in embryonic development, cell proliferation, survival, differentiation, chemotaxis, and migration. Critical for blood vessel development, it promotes the proliferation, migration, and recruitment of pericytes and smooth muscle cells to endothelial cells. It also contributes to vascular smooth muscle cell migration and neointima formation at injury sites, and is required for normal cardiovascular system development, pericyte (mesangial cell) recruitment in kidney glomeruli, and glomerular capillary network formation. The receptor induces actin cytoskeleton rearrangement and membrane ruffle formation. Ligand binding activates multiple signaling cascades, phosphorylating PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1, and NCK1, thereby regulating downstream effectors such as diacylglycerol, inositol 1,4,5-trisphosphate, Ca²⁺ mobilization, protein kinase C, AKT1, HRAS, RAF1, and MAPK1/ERK2/MAPK3/ERK1. Receptor signaling is downregulated by phosphatase-mediated dephosphorylation and rapid internalization. by similar: It also promotes phosphorylation and activation of SRC family kinases, PDCD6IP/ALIX, and STAM.

P09619

Predicted band size: 124 kDa; Observed band size: 190 kDa

Affinity Chromatography

Non-conjugated

Phosphorylated

AB_3105430

Cardiovascular

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Mouse, Rat

WB: 1/500-1/1000;IF: 1/50-1/200

WB, ICC/IF

Liquid

Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Phospho-PDGF Receptor beta (Y740)