2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Endogenous Metabolite Cannabinoid Receptor
  4. Virodhamine

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.

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Virodhamine

Virodhamine Chemical Structure

CAS No. : 287937-12-6

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Other Forms of Virodhamine:

Virodhamine Related Antibodies

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Description

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases[1][2].

In Vitro

Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus[1].
Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1[1].
Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control[1].
Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Virodhamine Related Antibodies

RT-PCR[1]

Cell Line: Megakaryocyte cell line
Concentration: 10, 20 and 40 μM
Incubation Time: 72 h
Result: Dose‐dependently enhanced the expression level of megakaryocytic marker CD61 and the expression of TRPV1 mRNA.
In Vivo

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety[2]
Dosage: 1, 5 and 10 mg/kg
Administration: Intraperitoneal injection; 1-10 mg/kg; once
Result: Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.
Molecular Weight

347.53

Formula

C22H37NO2
CAS No.
Appearance

Viscous Liquid

Color

Yellow to brown

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCCN)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Virodhamine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Virodhamine287937-12-6Endogenous MetaboliteCannabinoid ReceptorendocannabinoiMAPKROSmegakaryocytic differentiationneurological disorderAlzheimer's disease Parkinson's diseaseInhibitorinhibitorinhibit

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