2. Protein Tyrosine Kinase/RTK Apoptosis Epigenetics Cell Cycle/DNA Damage Stem Cell/Wnt JAK/STAT Signaling PI3K/Akt/mTOR MAPK/ERK Pathway
  3. Anaplastic lymphoma kinase (ALK) Apoptosis ROS Kinase Caspase PARP IGF-1R STAT Akt JNK
  4. ASP3026 (Standard)

ASP3026 (Standard) is the analytical standard of ASP3026. This product is intended for research and analytical applications. ASP3026 is a selective and orally active inhibitor of anaplastic lymphoma kinase (ALK). ASP3026 is a selective and oral active anaplastic lymphoma kinase (ALK) inhibitor with a IC50 value of 3.5 nM. ASP3026 can inhibit the phosphorylation of IGF-1R, STAT3, AKT and JNK proteins, and induce the cleavage of caspase 3 and PARP. It also inhibited ROS and ACK. ASP3026 can be used in anti-tumor research.

For research use only. We do not sell to patients.

ASP3026 (Standard) Chemical Structure

ASP3026 (Standard) Chemical Structure

CAS No. : 1097917-15-1

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Description
Molecular Weight

580.74

Formula

C29H40N8O3S
CAS No.
SMILES

COC(C=C(N1CCC(N2CCN(C)CC2)CC1)C=C3)=C3NC4=NC=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=N4
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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ASP3026 (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP3026 (Standard)1097917-15-1Anaplastic lymphoma kinase (ALK)ApoptosisROS KinaseCaspasePARPIGF-1RSTATAktJNKAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246poly ADP ribose polymerase Insulin-like growth factor-1 receptorPKBProtein kinase Bc-Jun N-terminal kinaseapoptosisanticancerNCI-H2228 cellnon-small cell lung cancer (NSCLC)NPM-ALK+ T-cellanaplastic large-cell lymphoma (ALCL)proliferationcell viabilityInhibitorinhibitorinhibit

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