2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. Death Receptor 5
  7. TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His)

TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P78567
Handling Instructions Technical Support

TRAIL R2/TNFRSF10B Protein serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC). This activation leads to a cascade of caspases, mediating apoptosis. TRAIL R2/TNFRSF10B lacks conserved residue(s) crucial for feature annotation propagation. TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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Description

TRAIL R2/TNFRSF10B Protein serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC). This activation leads to a cascade of caspases, mediating apoptosis. TRAIL R2/TNFRSF10B lacks conserved residue(s) crucial for feature annotation propagation. TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.
Background

TRAIL R2/TNFRSF10B Protein functions as a receptor for the cytotoxic ligand TNFSF10/TRAIL. Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC). Caspase-8 is then proteolytically activated, initiating a cascade of caspases that mediate apoptosis. Notably, TRAIL R2/TNFRSF10B lacks conserved residue(s) necessary for the propagation of feature annotation.
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

A0A2K5TXK0 (I58-S212)
Gene ID

102133727
Molecular Construction
N-term
TRAIL-R2 (I58-S212)
Accession # A0A2K5TXK0
His
C-term
Synonyms
TNFRSF10B; TRAILR2; TRAIL-R2; CD262; DR5; KILLER; TRICK2; ZTNFR9; TRICKB
Molecular Weight

25-35 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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