2. Immunology/Inflammation
  3. Interleukin Related
  4. Lusvertikimab

Lusvertikimab  (Synonyms: OSE-127)

Cat. No.: HY-P99412 Purity: 99.41%
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Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research.

For research use only. We do not sell to patients.

CAS No. : 2375835-91-7

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Based on 1 publication(s) in Google Scholar

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Description

Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target[1]

IL7R

 

In Vitro

OSE-127 (4 days) blocks STAT5 phosphorylation in IL7-dependent ALL cell lines and patient derived xenograft (PDX) samples[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lusvertikimab Related Antibodies
In Vivo

OSE-127 treated mice shows a reduction of peripheral blood (PB) blasts in 21/22 (95%) PDX samples in vivo when the corresponding control mice showed clinical signs of overt leukemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

145640.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Lusvertikimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation
References
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Lusvertikimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lusvertikimab2375835-91-7OSE-127OSE127OSE 127Interleukin RelatedILIL7Rheterodimerizationanti-leukemicB cellacute lymphoblastic leukemiaBCP-ALLInhibitorinhibitorinhibit

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