2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FAK Pyk2 IGF-1R Insulin Receptor Apoptosis
  4. NVP-TAE 226 (Standard)

NVP-TAE 226 (Standard) is the analytical standard of NVP-TAE 226. This product is intended for research and analytical applications. NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively.

For research use only. We do not sell to patients.

NVP-TAE 226 (Standard) Chemical Structure

NVP-TAE 226 (Standard) Chemical Structure

CAS No. : 761437-28-9

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SMILES

O=C(C1=C(C=CC=C1)NC2=NC(NC3=C(C=C(C=C3)N4CCOCC4)OC)=NC=C2Cl)NC
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Room temperature in continental US; may vary elsewhere.
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NVP-TAE 226 (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-TAE 226 (Standard)761437-28-9FAKPyk2IGF-1RInsulin ReceptorApoptosisPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseProline-rich tyrosine kinase 2Insulin-like growth factor-1 receptorInhibitorinhibitorinhibit

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