2. Immunology/Inflammation
  3. MHC
  4. Anti-Rat TCR alpha/beta Antibody (R73)

Anti-Rat TCR alpha/beta Antibody (R73) 

Cat. No.: HY-P990160
Technical Support

Anti-Rat TCR alpha/beta Antibody (R73) is an anti-mouse TCR alpha/beta IgG1 monoclonal antibody. Anti-Rat TCR alpha/beta Antibody (R73) suppresses immune response by depleting α/β+ T cells. Anti-Rat TCR alpha/beta Antibody (R73) can inhibit the expression of pro-inflammatory cytokines. Anti-Rat TCR alpha/beta Antibody (R73) can extend graft survival time by reducing infiltration of T cells and neutrophils. Anti-Rat TCR alpha/beta Antibody (R73) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as arthritis, acute inflammatory peripheral neuropathy and diabetes.

For research use only. We do not sell to patients.

Anti-Rat TCR alpha/beta Antibody (R73)

Anti-Rat TCR alpha/beta Antibody (R73) Chemical Structure

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anti-Rat TCR alpha/beta Antibody (R73) Related Antibodies

Top Publications Citing Use of Products

View All MHC Isoform Specific Products:

View All Isoforms
MHC I MHC II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Rat TCR alpha/beta Antibody (R73) is an anti-mouse TCR alpha/beta IgG1 monoclonal antibody. Anti-Rat TCR alpha/beta Antibody (R73) suppresses immune response by depleting α/β+ T cells. Anti-Rat TCR alpha/beta Antibody (R73) can inhibit the expression of pro-inflammatory cytokines. Anti-Rat TCR alpha/beta Antibody (R73) can extend graft survival time by reducing infiltration of T cells and neutrophils. Anti-Rat TCR alpha/beta Antibody (R73) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as arthritis, acute inflammatory peripheral neuropathy and diabetes[1][2][3][4].

Isotype

Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Rat
In Vivo

Anti-Rat TCR alpha/beta Antibody (R73) (100 μg, i.p., on day 14, 15, 16, 17, 18, 20 and 22) significantly inhibits the progression of arthritis in female Dark Agouti mice with an established adjuvant arthritis (EAA) model[1].
Anti-Rat TCR alpha/beta Antibody (R73) (0.5 mg/kg, i.v., once daily, for 5 days) significantly reduces blood sugar levels combined with IL-6 mAb and IL-17A mAb (HY-P990222) in IDDM rats with a diabetes model[2].
Anti-Rat TCR alpha/beta Antibody (R73) (0.1 mg/kg, i.p., once daily, for 7 days) significantly prolongs the survival time of kidney transplants in BN rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CFA induced female Dark Agouti mice (90-100 g)[1]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), on day 14, 15, 16, 17, 18, 20 and 22
Result: Significantly inhibited the progression of arthritis.
Significantly reduced synovial hyperplasia and inflammatory cell infiltration.
Caused mild cartilage erosion.
Effectively eliminated T cells from peripheral blood and synovial tissue.
Inhibited cellular immune response.
Animal Model: IDDM rats[2]
Dosage: 0.5 mg/kg, combined with IL-6 mAb (0.01 mg/kg) and IL-17A mAb (0.1 mg/kg)
Administration: Intravenous injection (i.v.), once daily, for 5 days
Result: Significantly reduced blood sugar to normal levels.
Significantly increase the quality of β cells.
Reduced pancreatic islet immune cell infiltration.
Reduced the apoptosis rate of β cells and promoted β cell proliferation.
Animal Model: BN rats (10-14 weeks)[3]
Dosage: 0.1 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily, for 7 days
Result: Significantly prolonged the survival time of kidney transplants (long-term survival or complete acceptance of transplants).
Reduced the levels of IgM and IgG homologous antibodies.
Upregulated Th2 cytokines (IL-4 and IL-10) in the transplant and inhibited Th1 cytokines (IL-2 and IFN-γ).
Significantly reduced the infiltration of T cells and neutrophils within the graft.
Inhibited the expression of pro-inflammatory cytokines (IL-1β and TNF-α) in the graft.
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Rat TCR alpha/beta Antibody (R73)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Rat TCR alpha/beta Antibody (R73) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Rat TCR alpha/beta Antibody (R73)MHCMajor Histocompatibility ComplexTCR alpha/betaT cellsxenotransplantationdiabetesarthritisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-Rat TCR alpha/beta Antibody (R73)
Cat. No.:
HY-P990160
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.