2. Apoptosis Stem Cell/Wnt MAPK/ERK Pathway
  3. Ferroptosis ERK MEK p38 MAPK
  4. Ferroptosis inducer-7

Ferroptosis inducer-7 is an orally active and selective ferroptosis inducer via inositol 1,4,5-trisphosphate receptor (IP3R)/calcium release-activated calcium channel protein (ORAI). Ferroptosis inducer-7 exhibits a notable effect in alleviating anemia symptoms, suppressing bone marrow CTLs activation, and improving hematopoietic function in immune-mediated bone marrow failure. Ferroptosis inducer-7 can be studied in research for aplastic anemia.

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Ferroptosis inducer-7 Chemical Structure

Ferroptosis inducer-7 Chemical Structure

CAS No. : 2723569-00-2

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Ferroptosis inducer-7 Related Antibodies

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Description

Ferroptosis inducer-7 is an orally active and selective ferroptosis inducer via inositol 1,4,5-trisphosphate receptor (IP3R)/calcium release-activated calcium channel protein (ORAI). Ferroptosis inducer-7 exhibits a notable effect in alleviating anemia symptoms, suppressing bone marrow CTLs activation, and improving hematopoietic function in immune-mediated bone marrow failure. Ferroptosis inducer-7 can be studied in research for aplastic anemia[1].

In Vitro

Ferroptosis inducer-7 (Compound 3a-M1) (1-10 μM, 72 h) significantly inhibits the proliferation of CD8+ T cells, as well as the release of IFN-γ and TNF-α in lymph nodes of BALB/c mice[1].
Ferroptosis inducer-7 (7.5-480 μM, 72 h) selectively inhibits the proliferation of cytotoxic lymphocyte line-2 (CTLL-2) compared to other immune cell lines[1].
Ferroptosis inducer-7 (7.5-30 μM, 16 h) suggests the inhibition of CTL function is due to the activation of Ferroptosis in CTLL-2 treated with IL-2[1].
Ferroptosis inducer-7 (10 μM, 45 min) increases the extracellular Ca2+ influx om CTLs, which is triggered by the IP3R /ORAI calcium channels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-7 Related Antibodies

Western Blot Analysis[1]

Cell Line: IL-2 stimulated CTLL-2 cell line
Concentration: 7.5-30 μM
Incubation Time: 16 h
Result: Showed a significant increase in the phosphorylation levels of mitogen-activated protein kinase, ERK and p38.
Activated the MEK/ERK and p38 MAPK signaling pathway.

Cell Viability Assay[1]

Cell Line: IL-2 stimulated CTLL-2 cell line
Concentration: 7.5-480 μM
Incubation Time: 72 h
Result: Showed the IC50 of Ferroptosis inducer-7 for IL-2-treated CTLL-2 (37.87 μM) was much lower than that for other immune cell lines, such as THP-1 (124.7 μM), HL-60 (132.6 μM), RAW264.7 (491.8 μM), HepG2 (491.9 μM), NRK-52E (705.1 μM), and IEC-6 (84.29 μM).
In Vivo

Ferroptosis inducer-7 (10 mg/kg, p.o., 14 d) not only exerts significant effects in alleviating anemia symptoms and improving hematopoietic function, but also has advantages in enhancing survival rates in immune-mediated bone marrow failure BALB/c mice model[1].
Ferroptosis inducer-7 (5-15 mg/kg, p.o., 21 d) improves survival rate, alleviates anemia symptoms, and improves hematopoietic function of immune-mediated bone marrow failure model in C57BL/6J mice model, particularly during the early stages of bone marrow failure[1].
Ferroptosis inducer-7 (5-15 mg/kg, p.o., one single dose) suppresses the proportion of T cells, especially CD8+ cells and CD8+/ CD4+ ratio in the bone marrow of aplastic anemia C57BL/6J mice[1].
Ferroptosis inducer-7 (10 g/kg, p.o., one single dose) causes no abnormalities in mice models, indicating the maximum tolerated dose exceeds 10 g/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immune-mediated bone marrow failure BALB/c mice model[1]
Dosage: 10 mg/kg, 14 d
Administration: Oral gavage (p.o.)
Result: Elevated body weight, peripheral red blood cells, hemoglobin levels, and platelet cells in mice.
Improved histopathological changes in the bone marrow, including increased nucleated cells, a restored nucleated-to-red blood cell ratio and a decrease in abnormal proportion of lymphocytes.
Animal Model: Aplastic anemia C57BL/6J mice[1]
Dosage: 5-15 mg/kg, one single dose
Administration: Oral gavage (p.o.)
Result: Reduced the proportion of effector CD8+ T cells, and increased memory CD8+ T cells.
Suppressed the level of IFN-γ and hyperactivation of CTLs in the bone marrow of AA mice.
Molecular Weight

489.56

Formula

C29H31NO6
CAS No.
SMILES

O=C(/C=C/C1=CC=CC=C1)OC2=C3[C@]45[C@@](C=C(C(C5)=O)OC)([H])[C@](N(CC4)C)([H])CC3=C(C=C2OC)CO
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Purity & Documentation
References
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Ferroptosis inducer-7 Related Classifications

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Keywords:

Ferroptosis inducer-72723569-00-2Ferroptosis inducer7Ferroptosis inducer 7FerroptosisERKMEKp38 MAPKExtracellular signal regulated kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KAAaplastic anemiaferroptosisinducerCTLsORAIIP3RInhibitorinhibitorinhibit

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