IL-17F Protein, Human (H161R, HEK293, His)

IL-17F protein is a key effector cytokine in innate and adaptive immunity that maintains tissue integrity and protects against microorganisms. It acts through the IL17RA-IL17RC receptor complex, activates the NF-kappa-B and MAPkinase pathways, and induces the transcription of immune-related genes. IL-17F Protein, Human (H161R, HEK293, His) is the recombinant human-derived IL-17F protein, expressed by HEK293 , with N-His labeled tag and H161R, , , , mutation. The total length of IL-17F Protein, Human (H161R, HEK293, His) is 133 a.a., with molecular weight of ~23 kDa.

IL-17F Protein serves as a key effector cytokine in the innate and adaptive immune systems, crucial for antimicrobial defense and tissue integrity maintenance. Operating through the IL17RA-IL17RC receptor complex, it triggers downstream activation of NF-kappa-B and MAPkinase pathways, leading to the transcriptional activation of various immune-related genes. Primarily associated with Th17 cells, IL-17F induces neutrophil activation, antimicrobial peptide production, and regulates immune tolerance. It forms homodimers and heterodimers with IL-17A, influencing diverse biological processes, from sympathetic innervation to microbiota regulation. The complex interactions and signaling pathways orchestrated by IL-17F underscore its multifaceted role in immune responses and cellular homeostasis.

Human

HEK293

N-His

Q96PD4 (R31-Q163, H161R)

112744  [NCBI]

Approximately 23 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.