2. Immunology/Inflammation
  3. STING Interleukin Related IFNAR
  4. hSTING activator-1

hSTING activator-1 (Compound 68) is a STING agonist. hSTING activator-1 can effectively activate multiple human STING variants (R232, H232, HAQ) with IC50 values of 56 nM, 89 nM and 51 nM, respectively. hSTING activator-1 activates the type I interferon pathway by directly binding to STING protein and stabilizing its conformation, promoting downstream IRF3 phosphorylation and cytokine release. hSTING activator-1 inhibits tumor growth and has potential in cancer research.

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hSTING activator-1 Chemical Structure

hSTING activator-1 Chemical Structure

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hSTING activator-1 Related Antibodies

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Description

hSTING activator-1 (Compound 68) is a STING agonist. hSTING activator-1 can effectively activate multiple human STING variants (R232, H232, HAQ) with IC50 values of 56 nM, 89 nM and 51 nM, respectively. hSTING activator-1 activates the type I interferon pathway by directly binding to STING protein and stabilizing its conformation, promoting downstream IRF3 phosphorylation and cytokine release. hSTING activator-1 inhibits tumor growth and has potential in cancer research[1].

Molecular Weight

470.52

Formula

C26H19FN4O2S
SMILES

O=C(C1=CC=C(S[C@@H](C)C2=NN=C(C3=CC=C(F)C=C3)N24)C4=C1)NCC(O5)=CC6=C5C=CC=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hSTING activator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hSTING activator-1hSTING activator1hSTING activator 1STINGInterleukin RelatedIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSILInterferon-α/β receptorInterferon-alpha/beta receptorH232R232HAQRAW cellshSTING.KI C57BL/6 miceInhibitorinhibitorinhibit

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