FGF Receptor 1 Antibody (YA4859)

FGF Receptor 1 Antibody (YA4859) is a mouse-derived and non-conjugated monoclonal antibody, targeting to FGFR1. It can be applicated for WB, ELISA assays, in the background of human.

FGF Receptor 1 is a tyrosine-protein kinase that functions as a cell-surface receptor for fibroblast growth factors (FGFs) and plays essential roles in regulating embryonic development, cell proliferation, differentiation, and migration. It is required for proper mesoderm patterning and axial organization during embryogenesis, normal skeletogenesis, and development of the gonadotropin-releasing hormone (GnRH) neuronal system. This receptor phosphorylates substrates including PLCG1, FRS2, GAB1, and SHB. Upon ligand binding, FGFR1 activates multiple signaling cascades: PLCG1 activation generates secondary messengers diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3); FRS2 phosphorylation mediates recruitment of GRB2, GAB1, PIK3R1, and SOS1 to activate RAS-MAPK (MAPK1/ERK2, MAPK3/ERK1) and AKT1 pathways; it also promotes phosphorylation of SHC1, STAT1, and PTPN11/SHP2. In the nucleus, FGFR1 enhances RPS6KA1 and CREB1 activity to regulate transcription. Its signaling is negatively regulated by IL17RD/SEF and through ubiquitination, internalization, and degradation mechanisms.

P11362

Predicted band size: 92 kDa; Observed band size: 92-140 kDa

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant extracellular fragment of human Flg (aa22-376) fused with hIgGFc tag expressed in HEK293 cells.