beta III Tubulin Antibody (YA4243)

beta III Tubulin Antibody (YA4243) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TUBB3. It can be used as a loading control antibody.

TUBB3 is a key member of the tubulin family, forming microtubules primarily composed of alpha- and beta-tubulin heterodimers. Microtubules grow by adding GTP-tubulin dimers at their ends, forming a stabilizing cap. Below this cap, alpha-beta tubulin heterodimers remain in a GDP-bound state due to alpha-tubulin's GTPase activity. TUBB3 plays a critical role in axon guidance and maintenance. The binding of NTN1/Netrin-1 to its receptor UNC5C may dissociate UNC5C from polymerized microtubules, increasing microtubule dynamics and mediating axon repulsion. It also contributes to dorsal root ganglion axon projection toward the spinal cord.

Q13509

Predicted band size: 50 kDa; Observed band size: 50 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human, Mouse, Rat

WB: 1:500-1:2000; IF: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000

WB, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human TUBB3 full(aa 1-450).